Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria

By A. Macpherson, T. Uhr. Science, 2004

1,593 citations recorded by the source corpus.

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In Immunology

Citations in the corpus

Monocyte-mediated defense against microbial pathogens. (2008, background): “Intestinal DCs promote IgA synthesis by B cells and may prevent mucosal dissemination by commensal bacteria (68,195).”
The regulation of IgA class switching (2008, background): “These antibodies mediate immune exclusion of commensals and provide limited protection against some pathogens, including rotaviruses and Salmonella typhimurium”
Mining the human gut microbiota for immunomodulatory organisms (2017, neutral): “, 2016) and by myeloid cells that actively transport the bacteria, plausibly to enable antigen presentation (Macpherson and Uhr, 2004; Diehl et al., 2013).”
Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells (2005, result): “This is consistent with published data showing that commensal bacteria are not simply 'ignored' or tolerized by the immune system; instead, they promptly induce IgA responses that are mediated by mucosal DC”
Impact of antibiotics on the human microbiome and consequences for host health (2022, background): “…(Szentkuti et al., 1990), reduced gastric motility (Abrams & Bishop, 1967), improper development and functioning of intestinal cells and immune cells (Cahenzli et al., 2013; Vaishnava et al., 2008) and improper development of the immune system (Bauer et al., 1963; Macpherson & Uhr, 2004).”
The gut flora as a forgotten organ (2006, background): “Dendritic cells can ingest and retain live commensal bacteria and travel to the mesenteric lymph node where immune responses to commensal bacteria are induced locally (Macpherson & Uhr, 2004).”
Role of the Microbiota in Immunity and inflammation (2014, background): “IgA specific for commensals is produced with the help of intestinal dendritic cells that sample commensals associated with the epithelium and interact with B and T cells in the Peyer’s patches to produce IgA specific for commensal-derived antigens (Macpherson and Uhr, 2004).”
Multi-Faceted Functions of Secretory IgA at Mucosal Surfaces (2013, background): “Commensal bacteria associated with local DC in the subepithelial dome region do not penetrate further than the draining mesenteric lymph nodes, resulting in the confinement of immune induction against the microbiota to the mucosa (142, 143).”
Toll-like receptor control of the adaptive immune responses (2004, background): “Because commensal bacteria can be taken up by DCs in the Peyer's patc”
Mechanisms of probiotic actions - A review. (2010, background): “Another direct contact between probiotics and host cells in the gut occurs by internalization of bacteria by DCs which are localized below the epithelial cells (non M-cells) (Macpherson and Uhr, 2004).”
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5 (2008, background): “and induce the differentiation of plasma cells positive for immunoglobulin A (IgA”
War and peace at mucosal surfaces (2004, background): “Owing to their lack of surface glycocalyx and their high endocytic activity, M cells sample commensal bacteria and transfer them to DCs, in which a small number of bacteria can survive and induce T-cell-independent IgA responses, which are thought to account for the regulation of endogenous bacteri”