The gut flora as a forgotten organ

By A. M. O'Hara, F. Shanahan. EMBO Reports, 2006

2,718 citations recorded by the source corpus.

Subfields: Food Science, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/056ee21c95a3acc6ca1d962ec77de0df5e28b993

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Citations in the corpus

The gut microbiome shapes intestinal immune responses during health and disease (2009, neutral): “In addition to the crucial role of genetic factors in determining susceptibility to IBD, some investigators have suggested that IBD results, at least in part, from dysbiosis of the microbiota and not because of the acquisition of an infectious agen”
Metabolomics for Investigating Physiological and Pathophysiological Processes. (2019, background): “The gut microbiome is now considered an essential organ (29, 354), as without it, humans are unable to develop a fully functional immune system, generate essential vitamins, or digest foods very efficiently.”
Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis (2011, background): “The commensal microbiota of the intestine is vital for many physiological and homeostatic function”
Probiotics and prebiotics in animal feeding for safe food production. (2010, background): “Thus there is evidence of a correlation between the composition of the colonizing microbiota and variations in immunity (O'Hara and Shanahan, 2006).”
Human gut microbiota/microbiome in health and diseases: a review (2020, background): “Among these genera, Bacteroides being the most abundant one; species from this family alone comprise about 30% of bacteria in the gut suggests that this genus is particularly significant in the functioning of the host organism (Ann and Fergus 2006).”
Minireview: Gut microbiota: the neglected endocrine organ. (2014, background): “It is likely that fecal, luminal, and mucosal bacterial populations represent distinct ecological niches in addition to the considerable variation along the known gradient of bacteria in the GI tract (18).”
The role of microbiome in central nervous system disorders (2013, neutral): “In line with these concepts, germ-free (GF) animals have higher susceptibility to infection but reduced digestive enzyme activities and muscle wall thickness (O’Hara and Shanahan, 2006; Round and Mazmanian, 2009).”
The Impact of the Gut Microbiota on Human Health: An Integrative View (2012, neutral): “It appears that both the innate and adaptive immune systems have evolved to require microbial interactions during their development (Chow et al., 2010; O’Hara and Shanahan, 2006).”
Proteobacteria: A Common Factor in Human Diseases (2017, background): “gram in jejunum and ileum, to 10(11)-10(12) microbes per gram in the colon [7, 8].”
Lactobacillus plantarum promotes Drosophila systemic growth by modulating hormonal signals through TOR-dependent nutrient sensing. (2011, background): “Hence, the idea that the intestinal microbiota constitutes an additional organ has recently re-emerged (Bocci, 1992; O’Hara and Shanahan, 2006).”
Safety assessment of probiotics for human use (2010, background): “The indigenous intestinal microbiota is known to be pivotal for the development and maintenance of gut physiology and immune homeostasis.(19) The gut acts as a highly selective barrier and communication organ between the luminal bacterial environment and the host.”