Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells

By M. Rimoldi, M. Chieppa, V. Salucci, F. Avogadri, A. Sonzogni, G. Sampietro, A. Nespoli, G. Viale, P. Allavena, M. Rescigno. Nature Immunology, 2005

861 citations recorded by the source corpus.

Subfields: Dermatology, Immunology

View Paper: https://www.semanticscholar.org/paper/31652870f1186b0cdf4eccfa55f313e949b228e0

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In Dermatology

1. Wenjun Ouyang
2. Yan Zheng

In Immunology

1. O. Joffre
2. M. Nolte
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4. Markus F. Neurath
5. D. Artis
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Citations in the corpus

• Dendritic cells in intestinal immune regulation (2008, positive): “In fact, following in vitro co-culture with an epithelial-cell line, human DCs preferentially induced non-inflammatory T H 2-type response”
• Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut (2008, background): “In addition, a subset of myeloid DCs that are distinguished by their expression of CX 3 CR1 are resident in the lamina propria of the jejunum and proximal ileum of the small intestine and have the capacity to extend their dendrites between the tight junctions of IECs to take up luminal bacteri”
• Inflammatory signals in dendritic cell activation and the induction of adaptive immunity (2009, background): “that the latter respond to bacterial presence by releasing IL-10 and IL-6, but not IL-12, and promote Th2 rather than Th1 responses (35).”
• Protective immune mechanisms in helminth infection (2007, background): “In vitro studies suggest that intestinal epithelial cells (IECs) secrete factors, including thymic stromal lymphopoietin ( TSLP ), that block the production of IL-12 by DCs and thereby inhibit the ability of DCs to promote T H 1-type response”
• Intestinal barrier and gut microbiota: Shaping our immune responses throughout life (2017, background): “the intestinal mucosa such as DCs and Treg cells.(102,103) Furthermore, reactive oxygen species (ROS) have been detected in the ageing ENS, for example, higher production of ROS is found in myenteric neurons in the ileum of old rats compared to young animals.”
• A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease (2019, background): “IEC isolated from about 70% of patients with Crohn’s disease do not express TSLP mRNA and cannot control the DC-mediated proinflammatory response, leading to upregulated production of IL-12 by DCs, which then polarizes Th1 responses [69].”
• Probiotics and immunity (2009, background): “The production of TGF-β and thymic stromal lymphopoietin by intestinal epithelial cells has been implicated in the induction of this tolerogenic DC phenotype.(42,50) Probiotics in clinical practice”
• Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells (2007, background): “The up-regulation of TSLP by bacterial products is, however, not restricted to airway epithelial cells as it has been shown in intestinal epithelial cells (23).”
• STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing (2009, background): “In contrast, CD11c+ DCs are present in significant numbers in the colon of healthy animals and are strategically located directly underneath the surface epithelium (Rimoldi et al., 2005).”