Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

By Satoshi Uematsu, K. Fujimoto, M. Jang, Bo-Gie Yang, Y. Jung, Mika Nishiyama, Shintaro Sato, T. Tsujimura, Masafumi Yamamoto, Y. Yokota and 4 more. Nature Immunology, 2008

804 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/28f1c9120b6e161ef03692aa9bbed0403c31852e

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In Immunology

Citations in the corpus

The Microbiome in Infectious Disease and Inflammation (2012, positive): “TLR9-deficient mice have decreased numbers of LP Th17 cells (153), and in vitro differentiation of intestinal Th17 cells is enhanced by the addition of flagellin, a ligand for TLR5 (76) and NLRC4 inflammasomes (154, 155).”
Tissue-specific signals control reversible program of localization and functional polarization of macrophages. (2014, neutral): “B-1 cells of peritoneal cavity are thought to directly migrate into intestinal lamina propria and give rise to IgA-secreting cells in a manner that is independent of gut-associate lymphoid tissue (GALT) (Fagarasan et al., 2010; Uematsu et al., 2008).”
Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions (2009, background): “Given previous studies suggesting that CX3CR1+ cells capture luminal antigen for initiation of immune responses (Niess et al., 2005; Chieppa et al., 2006; Niess and Reinecker, 2006; Vallon-Eberhard et al., 2006; Hapfelmeier et al., 2008; Uematsu et al., 2008) and indirect evidence indicating that at”
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. (2011, background): “Indeed, IL-1 receptor-deficient mice are protected against S. aureus-induced sepsis and show reduced cytokine production and impaired neutrophil recruitment in cutaneous infection models (Verdrengh et al., 2004).”
Intestinal lamina propria dendritic cell subsets have different origin and functions. (2009, background): “Furthermore, TLR5 CD11b lpDCs were shown to induce IgA class switch recombination of B cells through provision of APRIL (Uematsu et al., 2008).”
Homeostatic immunity and the microbiota (2017, positive): “…by rapidly expressing chemokines, antimicrobial peptides and cytokines involved in the initiation of immune responses (Kinnebrew et al., 2012; Uematsu et al., 2008; Uematsu et al., 2006) and Unmethylated cytosine phosphate guanosine (CpG) dinucleotides, which are abundant within the…”
IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses (2013, background): “Previous data highlighted the specific expression of IL-23 by a subset of SI-LP TLR5+CD11b+ DCs promoting Th17 T helper cells (Uematsu et al., 2008), and by flagellin-stimulated CD11b+CD103+ DCs (Kinnebrew et al., 2012).”
Specific microbiota direct the differentiation of Th17 cells in the mucosa of the small intestine (2008, positive): “Cell Ho We also investigated whether signaling downstream of TLRs, which detect microbial products and have been implicated in Th17 cell differentiation (Uematsu et al., 2008; Veldhoen et al., 2006), is required for induction of the Th17 lineage.”
Pattern recognition receptors and inflammation. (2010, background): “In response to flagellin, LPDCs induce B cells to differentiate into IgA-producing plasma cells and trigger the differentiation of naive T cells into antigen-specific Th17 and Th1 cells (Uematsu et al., 2008).”
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors (2010, background): “CD11c + CD11b + lamina propria DCs in the small intestine have high TLR5 expressio”