Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation.

By J. Feige, Marie Lagouge, C. Cantó, Axelle Strehle, Sander M. Houten, J. Milne, P. Lambert, C. Mataki, P. Elliott, Johan Auwerx. Cell Metabolism, 2008

785 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/24520fe7acb61f76e8b2a848884a8752b877dbdd

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In Geriatrics and Gerontology

In Physiology

Citations in the corpus

Calorie restriction-like effects of 30 days of Resveratrol (resVida™) supplementation on energy metabolism and metabolic profile in obese humans (2011, background): “…al., 2009; Pacholec et al., 2010), but rather exerts its effects on SIRT1 through activation of AMPK (Baur et al., 2006; Cantó et al., 2009, 2010; Feige et al., 2008; Hawley et al., 2010; Um et al., 2010), although additional direct SIRT1 activation is not completely excluded (Dai et al., 2010).”
TGR5-mediated bile acid sensing controls glucose homeostasis. (2009, methodology): “The specificity of INT-777 for TGR5 was further confirmed by its inability to activate a subset of nuclear receptors involved in lipid and xenobiotic metabolism (Figure S1A), as well as other GPCRs that are phylogenetically related to TGR5 (Figures S1B and S1C).”
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. (2010, background): “The relevance of SIRT1 in the control of whole body glucose homeostasis is the result of the combined action on different tissues (101, 102), and it has a critical role during fasting (103).”
Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases (2012, positive): “Because the metabolic effects of SRT1720 are nearly identical to those of resveratrol (Milne et al., 2007; Feige et al., 2008), it is tempting to speculate that these compounds, or at least SRT1720, act via pathways similar to those of resveratrol.”
Regulation of SIRT1 and Its Roles in Inflammation (2022, background): “Interestingly, SIRT1 can indirectly activate AMPK signaling in the process of chronic metabolic adaptations (70).”
Resveratrol and health--a comprehensive review of human clinical trials. (2011, background): “Intriguingly, some of the beneficial effects of resveratrol appear to be replicated by overexpression of SIRT1 [16], or by treatment with a structurally unrelated SIRT1 activator [17], and animals that lack AMPK fail to exhibit many of the normal responses to resveratrol [18].”
SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM (2012, background): “Interestingly, this interaction between SIRT1 and AMPK seems to be reciprocal, as SIRT1 activation stimulates fatty acid oxidation and indirectly activates AMPK (99).”
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function (2012, background): “…treatment of mice with a SIRT1 activator that is structurally unrelated to resveratrol, SRT1720, increases mitochondrial capacity in skeletal muscle (Feige et al., 2008) and liver in a SIRT1-dependent manner (Minor et al., 2011), while improving the health and survival of mice on a high fat diet,…”