The sirtuin SIRT6 regulates lifespan in male mice

By Y. Kanfi, Shoshana Naiman, G. Amir, Victoria Peshti, Guy E. Zinman, Liat Nahum, Ziv Bar-Joseph, H. Cohen. Nature, 2012

969 citations recorded by the source corpus.

Subfields: Aging, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/6a17bf78a887437a24e678de9caf0f374ede15e8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. L. Guarente
2. Johan Auwerx
3. Guido Kroemer
4. C. Cantó
5. Manuel Serrano
6. Hung-Chun Chang
7. S. Imai
8. Keir J. Menzies

In Geriatrics and Gerontology

1. Johan Auwerx
2. C. Cantó
3. S. Imai
4. L. Guarente
5. Keir J. Menzies
6. Hung-Chun Chang
7. Guido Kroemer
8. T. Arnesen

In Physiology

1. Johan Auwerx
2. S. Imai
3. C. Cantó
4. Guido Kroemer
5. Keir J. Menzies
6. Manuel Serrano
7. Hung-Chun Chang
8. L. Guarente

Citations in the corpus

• The hallmarks of aging. (2013, background): “, 2006), whereas male transgenic mice overexpressing SIRT6 have a longer lifespan than control animals, associated with reduced serum IGF1 and other indicators of IGF-1 signaling (Kanfi et al., 2012).”
• NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus (2015, background): “…et al., 2005), most data agree that sirtuin activation in mammals delays the onset of agerelated degenerative processes (Herranz et al., 2010; Kanfi et al., 2012; Pearson et al., 2008; Satoh et al., 2013) and that defective sirtuin activity impairs some of themetabolic and physiological…”
• The world of protein acetylation. (2016, background): “Male mice who overexpress SIRT6, on the other hand, have increased lifespan [438].”
• NAD+ and Sirtuins in Aging and Disease (2014, background): “In mammals, it has been reported that whole-body Sirt6 transgenic mice show lifespan extension, in males (17).”
• NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential (2020, background): “For instance, both brain-specific or whole-body SIRT1-overexpressing transgenic mice exhibit a slowed aging and a prolonged lifespan.(347,348)”
• Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. (2013, background): “On the other hand, a recent study has demonstrated that wholebody Sirt6-overexpressing transgenic mice show significant life span extension, although it was observed only in males (Kanfi et al., 2012).”
• SIRT1 and other sirtuins in Metabolism (2013, background): “SIRT1, SIRT6 and SIRT7 are localized in the nucleus, where they function to deacetylate histones thereby influencing gene expression epigenetically [14].”
• THE HISTONE DEACETYLASE SIRT6 IS A NOVEL TUMOR SUPPRESSOR THAT CONTROLS CANCER METABOLISM (2012, neutral): “that male mice overexpressing SIRT6 have increased life span compared to control animals (Kanfi et al., 2012).”