Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha.

By Ji‐Hong Lim, Yoon-Mi Lee, Y. Chun, Junjie Chen, Ja-Eun Kim, Jong-Wan Park. Molecules and Cells, 2010

781 citations recorded by the source corpus.

Subfields: Cancer Research, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/e73da39ee6f68639bdee45cc345ec7c3b66950a7

How researchers see this paper

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In Cancer Research

1. Michael D. Buck
2. Ping Gao
3. Jiangwen Zhang
4. E. Seto
5. R. Sowell
6. Erika L. Pearce
7. S. Kaech
8. P. Pandolfi

In Geriatrics and Gerontology

1. Bor Luen Tang
2. Luis A. Rajman
3. D. Sinclair
4. M. Haigis
5. E. Seto
6. Ping Gao
7. Lydia W. S. Finley
8. Huafeng Zhang

In Physiology

1. Bor Luen Tang
2. Luis A. Rajman
3. D. Sinclair
4. M. Haigis
5. E. Seto
6. Arkaitz Carracedo
7. Ping Gao
8. C. Palmeira

Citations in the corpus

• Regulation of SIRT1 and Its Roles in Inflammation (2022, background): “Through this interaction, SIRT1 inactivates HIF1a by blocking the recruitment of P300 acetyltransferase in hypoxia (140).”
• Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging (2013, background): “Interestingly, SIRT1 increases HIF-1a transcriptional activity (Lim et al., 2010), SIRT3 destabilizes HIF-1a protein (Bell et al., 2011; Finley et al., 2011), and SIRT6 functions as a HIF-1a corepressor (Zhong et al., 2010), raising the possibility that HIF-1amay also be relevant to aging.”
• Sirt1 and the Mitochondria (2016, background): “Sirt1 deacetylates and represses the activity of the hypoxia inducible factor 1-alpha (HIF-1α) (Lim et al., 2010).”
• Metabolic Instruction of Immunity (2017, positive): “SIRT1 was previously shown to negatively control HIF-1α as well as mTOR (Lim et al., 2010; Liu et al., 2013).”
• SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization (2011, background): “SIRT1 binds HIF1a and regulates its activity through direct deacetylation (Lim et al., 2010).”
• HDACs and HDAC Inhibitors in Cancer Development and Therapy (2016, positive): “The suppression of SIRT1 under hypoxic conditions provides a positive feedback loop that maintains a high level of HIF-1 activity (Lim et al. 2010).”
• Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “SIRT1 inhibits HIF-1α activity by blocking p300 recruitment, leading to downregulated glycolysis and retarded tumor growth (Lim et al., 2010).”
• SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM (2012, background): “In hypoxic conditions, SIRT1 is downregulated due to decreased NAD levels, which allows the acetylation and activation of HIF1 (199).”