Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease

By Marius Wernig, Jian-ping Zhao, J. Pruszak, E. Hedlund, Dongdong Fu, F. Soldner, V. Broccoli, M. Constantine‐Paton, O. Isacson, R. Jaenisch. Proceedings of the National Academy of Sciences of the United States of America, 2008

1,265 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8b63097ff7424c6656e2412908ee45f72cfda395

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. P. Carpentier
2. V. Tabar
3. T. Palmer
4. L. Studer
5. D. Surmeier
6. K. Hochedlinger
7. Fred H. Gage
8. Hongjun Song

In Molecular Biology

1. M. Stadtfeld
2. K. Hochedlinger
3. G. Daley
4. Daisy A. Robinton
5. Kathrin Plath
6. V. Tabar
7. M. Beal
8. T. Palmer

Citations in the corpus

• Induced pluripotency: history, mechanisms, and applications. (2010, background): “Only a subset of fibroblasts expressing reprogramming factors down-regulates somatic markers and activates pluripotency genes (Wernig et al. 2008a; Stadtfeld et al. 2010a), indicating that many cells are refractory to reprogramming or become so as a consequence of factor expression.”
• The promise of induced pluripotent stem cells in research and therapy (2012, background): “In another landmark study from Jaenisch's research group, Wernig and colleagues derived dopaminergic neurons from iPS cells that, when implanted into the brain, became functionally integrated and improved the condition of a rat model of Parkinson's diseas”
• Ethical and Safety Issues of Stem Cell-Based Therapy (2018, background): “Uncontrolled proliferation and differentiation of transplanted undifferentiated iPSCs may result in generation of tumors and/or undesired differentiation of iPSCs in broad range of somatic cells [27].”
• Floor plate-derived dopamine neurons from hESCs efficiently engraft in animal models of PD (2011, background): “Whereas mouse PSC-derived DA neurons have shown efficacy in models of Parkinson’s diseas”
• Immune Influence on Adult Neural Stem Cell Regulation and Function (2009, positive): “In a toxin-induced model of PD in rats (Wernig et al., 2008), the cells survived and integrated in the host brain, but the authors noted the appearance of teratomas arising from undifferentiated cells (Wernig et al.”
• Epigenetic reprogramming and induced pluripotency (2009, background): “When mouse or human fibroblasts derived from such iPS cells were treated with doxycycline, between 3-5% of the cells gave rise to iPS cells (Hockemeyer et al., 2008; Maherali et al., 2008; Wernig et al., 2008a) (Table 1).”
• Gene therapy clinical trials worldwide to 2012 – an update (2013, background): “in a rat model of Parkinson’s disease [82].”