Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis

By S. Pluchino, A. Quattrini, E. Brambilla, A. Gritti, G. Salani, G. Dina, R. Galli, U. Carro, S. Amadio, A. Bergami and 4 more. 2003

1,117 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Neurology, Pathology and Forensic Medicine

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Citations in the corpus

Adult neurogenesis in brain repair: cellular plasticity vs. cellular replacement (2014, background): “The therapeutic potential of the transplanted stem cells have been validated in various models of diseases and injuries (Shihabuddin et al., 2000; Pluchino et al., 2003; Cummings et al., 2005; Jin et al., 2005).”
Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism (2005, methodology): “had been immunized with 200 mg myelin oligodendrocyte glycoprotein (MOG)35–55 (Espikem) in CFA containing 500 ng pertussis toxin(2) or (2) SJL”
Remyelination in the CNS: from biology to therapy (2008, methodology): “Two experimental approaches have been developed: intraventricular and intravenous deliver”
Origin of Oligodendrocytes in the Subventricular Zone of the Adult Brain (2006, background): “Adult neural stem cells grown from the adult SVZ as neurospheres can generate oligodendrocytes (Morshead et al., 1994; Gritti et al., 1996; Weiss et al., 1996; Doetsch et al., 1999; Pluchino et al., 2003).”
Stem cells for the treatment of neurological disorders (2006, background): “Interestingly, after systemic administration in mice, NS cells migrated to inflammatory demyelinating lesions, where some became OPCs and remyelinated axon”
Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS) (2011, background): “Cell-based therapies Neural stem cells Improvement (Picard-Riera et al., 2002; Einstein et al., 2003; Pluchino et al., 2003; 2005; Einstein et al., 2006; Makar et al., 2008; Pluchino et al., 2009; Yang et al., 2009)”
Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood (2006, result): “In contrast, our results might explain why pathological conditions such as acute CNS insult and experimental autoimmune encephalomyelitis might be accompanied by an increase in neurogenesis as well as by the induction of neurogenesis in non-neurogenic area”
Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy (2016, background): “(75) reported similar functional improvements following transplantation of adult neural stem cell into an animal model of MS.”
BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “NPC transplantation in EAE mice attenuated the inflammatory process, rescued the endogenous pool of oligodendrocyte progenitor cells, reduced acute and chronic axonal injury and demyelination, and improved the overall clinical and neurophysiological performance of the mice (63, 175).”
Toll-like receptors modulate adult hippocampal neurogenesis (2007, methodology): “Adult NPCs from wild-type and from TLR-deficient mice were obtained as described previousl”
The blood-brain barrier in brain homeostasis and neurological diseases. (2009, neutral): “the BBB and to significantly improve the outcome of the corresponding disease [235–242].”