A protein interaction network for pluripotency of embryonic stem cells

By Jianlong Wang, Sridhar Rao, J. Chu, Xiaohua Shen, D. Levasseur, T. Theunissen, Stuart H. Orkin. Nature, 2006

1,198 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d80cd6a887eaeeb14efeca8206230d37406533b2

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Citations in the corpus

A Myc rather than core pluripotency module accounts for the shared signatures of embryonic stem and cancer cells (2010, neutral): “between Embryonic Stem and Cancer”
Klf4 reverts developmentally programmed restriction of ground state pluripotency (2009, background): “Both cell types express the three transcriptional regulators, Oct4 (Pou5f1 – Mouse Genome Informatics), Sox2 and Nanog, that are generally considered to constitute the core pluripotency network (Boyer et al., 2005; Loh et al., 2006; Wang et al., 2006).”
Mechanisms of stem cell self-renewal. (2009, background): “These three transcription factors interact physically with each other, and co-occupy regulatory regions in many target genes, coordinately regulating the pluripotent state (Boyer et al. 2005, Loh et al. 2006, Masui et al. 2007, Wang et al. 2006).”
Induced pluripotency: history, mechanisms, and applications. (2010, background): “…individual exogenously expressed factors to cognate DNA sequences, key components of the more elaborate activating complexes, such as Nanog or Dax1 (Wang et al. 2006), may be limiting or absent at early stages of reprogramming and may become available only late, when their respective endogenous…”
Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis (2017, background): “, 2013) and as a direct interactor of Dax1 (Wang et al., 2006).”
ChIP-Seq of transcription factors predicts absolute and differential gene expression in embryonic stem cells (2009, background): “Mass spectrometry analysis of Oct4 and Nanog interacting proteins suggests their potential partners, such as Nr0b1 , Nac1 , and Zfp281 (19).”
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. (2007, background): “The function of Oct3/4 and Sox2 as core transcription factors to determine pluripotency is well documented (Boyer et al., 2005; Loh et al., 2006; Wang et al., 2006).”
An extended transcriptional network for pluripotency of embryonic stem cells. (2008, methodology): “were expressed fail to elicit subsequent change in the transcript levels of the nine factors (Figure 1B) (Wang et al., 2006).”
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. (2008, background): “Although many recent studies have identified transcription factor networks and epigenetic processes that are fundamental to the maintenance of pluripotency (the stage where cells have the potential to differentiate into any germ layer) and differentiation of ES cells (Boyer et al. 2005; Boyer et al.”
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. (2008, methodology): “Tandem purification, coIP, and protein identification by LC-MS/MS were described previously (Wang et al., 2006).”
Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “New regulators of pluripotency (such as Esrrb, Dax1, Sall4, Rex1, Stat3, among others) have been identified by shRNA knockdown screens (Ivanova et al., 2006), proteomics (Wang et al., 2006) and analysis of transcription factor binding sites and gene expression data (Zhou et al., 2007).”
Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells (2009, neutral): “self-renew and differentiation (Pan et al., 2002; Wang et al., 2006) and very recently validated as a cancer stem cell target (Hu et al.”
How is pluripotency determined and maintained? (2007, background): “In addition, a recent protein interaction network analysis identified two transcription factors, the BTBdomain-containing protein Nac1 (Btbd14b – Mouse Genome Informatics) and the zinc-finger protein Zfp281, which interact with Nanog and are essential for maintaining the self-renewal of mouse ES cel”
Pluripotency: Toward a gold standard for human ES and iPS cells (2009, background): “Other factors required for pluripotency include Sall4, Dax1, Essrb, Tbx3, Tcl1, Rif1, Nac1 and Zfp281 (Ivanova et al., 2006; Loh et al., 2006; Wang et al., 2006; Zhou et al., 2007).”