Induction of pluripotent stem cells from adult human fibroblasts by defined factors.

By Kazutoshi Takahashi, K. Tanabe, M. Ohnuki, Megumi Narita, T. Ichisaka, K. Tomoda, S. Yamanaka. Cell, 2007

19,286 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/5c0b24e0468f66de0b126242b0fcdd90af526806

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Citations in the corpus

Module map of stem cell genes guides creation of epithelial cancer stem cells. (2008, background): “(Takahashi et al., 2007; Takahashi and Yamanaka, 2006).”
An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors (2008, background): “The recent demonstration that adult fibroblasts can be reprogrammed into pluripotent ES-like cell”
The potential of neural stem cells to repair stroke-induced brain damage (2009, background): “Because of the success of reprogramming diVerentiated human somatic cells into pluripotent stem cells [72, 79, 89, 115 , 145], we may soon have patient-speciWc stem cells that would avoid immune system rejection.”
Reprogramming of human primary somatic cells by OCT4 and chemical compounds. (2010, background): “…somatic cells into pluripotent cells that closely resemble embryonic stem cells (ESCs) by introduction of defined transcription factors (TFs), holds great potential in biomedical research and regenerative medicine (Takahashi and Yamanaka, 2006; Takahashi et al., 2007; Yu et al., 2007).”
Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency (2011, positive): “(F) Q-PCR for pluripotent stem cell marker genes shows enhanced expression of pluripotency markers at day 8 of reprogramming by miR302/367 in wild-type ( Total cell lysates were prepared for western blotting as previously described (Trivedi et al., 2008).”
CRISPRi-based genome-scale identification of functional long non-coding RNA loci in human cells (2016, neutral): “Here, we developed CRISPRi libraries targeting 16,401 lncRNA loci (with 10 sgRNAs per TSS) and conducted screens for genes that are required for robust growth in seven human cell types—six transformed cell lines and induced pluripotent stem cells (iPSCs) (36).”
A combined chemical and genetic approach for the generation of induced pluripotent stem cells. (2008, positive): “…into induced pluripotent stem (iPS) cells have opened up tremendous opportunities for the stem cell field (Maherali et al., 2007; Meissner et al., 2007; Nakagawa et al., 2008; Okita et al., 2007; Takahashi et al., 2007; Takahashi and Yamanaka, 2006; Wernig et al., 2007, 2008; Yu et al., 2007).”
Satellite cells and the muscle stem cell niche. (2013, background): “Over the last five years, various types of differentiated somatic cells have been successfully induced into pluripotent stem cells (iPS cells) via a process involving transcription factor based reprogramming (371, 384, 515, 516, 582).”