EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.

By Xiaohua Shen, Yingchun Liu, Y. Hsu, Y. Fujiwara, Jonghwan Kim, Xiaohong Mao, Guocheng Yuan, Stuart H. Orkin. Molecules and Cells, 2008

1,035 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/18b9c0dff853b81eeeca050ef2b1db766649ffda

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Citations in the corpus

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders (2010, background): “Orkin (Howard Hughes Medical Institute, Boston, Massachusetts, USA”
A double take on bivalent promoters. (2013, background): “…mild effects on self-renewal, all PRC2-deficient ES cells exhibit aberrant differentiation potential (Pasini et al. 2007; Chamberlain et al. 2008; Shen et al. 2008; Leeb et al. 2010), which parallels the post-implantation lethality phenotypes observed in PRC2 knockout mouse models (Faust et al.…”
Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. (2010, positive): “…Ezh2, Suz12, Eed, or Ring1b leads to a loss of H3K27me3 and H2AK119ub1 marks, a spontaneous increase in developmental gene expression, and consequently, differentiation defects of embryonic stem cells (Chamberlain et al., 2008; Pasini et al., 2007; Shen et al., 2008; van der Stoop et al., 2008).”
Epigenetic antagonism between Polycomb and SWI/SNF complexes during oncogenic transformation (2010, neutral): “p16 has also been shown to be a target of EZH2 and to be repressed by PcG-mediated silencing (Kia et al., 2008; Kotake et al., 2007; Shen et al., 2008).”
A Myc rather than core pluripotency module accounts for the shared signatures of embryonic stem and cancer cells (2010, neutral): “To obtain a global view of individual and multiple transcription factor occupancy, we combined this new data set with previously published ChIP-chip or ChIP-sequencing data sets (Boyer et al., 2006; Chen et al., 2008; Ding et al., 2009; Hu et al., 2009; Kim et al., 2008; Shen et al., 2008) and teste”
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas (2010, background): “Knockout studies of EZH2 and of another PRC2 subunit, EED, have demonstrated H3K27me1 formation can be catalyzed by PRC2 complexes containing either EZH2 or the related protein EZH1, as the catalytic subunit (22).”
Topologically-associating domains are stable units of replication-timing regulation (2014, positive): “Notably, SUZ12 is a component of the Polycomb Repressive Complex 2 responsible for the H3K27me3 modification 24 , and both SUZ12 and H3K27me3 were enriched at TTR-present RD boundaries in ESCs (Fig.”
Genome Regulation by Polycomb and Trithorax: 70 Years and Counting. (2017, positive): “MLL2 is responsible for H3K4 trimethylation at bivalent promoters in ESCs (Figure 2B) (Denissov et al., 2014), whereas MLL1 is required for H3K4 trimethylation at only a small subset of genes, including HOX genes, emphasizing the non-redundant function of these two histone methyltransferases.”
Transcriptional regulation by Polycomb group proteins (2013, background): “; and from the Novo Nordisk Foundation, the Danish Cancer Society and the Danish Council for Strategic Research (12-110503) to K.”
Mechanisms of Polycomb gene silencing: knowns and unknowns (2009, background): “Whereas EZH2 is highly expressed during embryogenesis and in proliferating cells, EZH1 predominates in adult tissues and non-dividing cell”
Mapping the Mouse Cell Atlas by Microwell-Seq. (2018, methodology): “…Lab RRID:CVCL_C316 Mouse: Embryonic stem cell (E14) George Q. Daley Lab RRID:CVCL_C320 Mouse: Ezh2 / Embryonic stem cell (Cj7) Stuart H. Orkin Lab Shen et al., 2008 Mouse: Trophoblast stem cell Janet Rossant Lab Tanaka et al., 1998 Human: 293T Stuart Orkin Lab RRID:CVCL_0063 Experimental Models:…”
Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells (2009, background): “Recently, Ezh1 was shown to function similarly to Ezh2 (Shen et al., 2008), which could explain the residual triMeK27-H3 modification in Ezh2 cKO epidermis.”
Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa (2010, background): “PRC2, which consists of Eed, Suz12 and Ezh2 or Ezh1, catalyzes trimethylation on histone H3 Lys27 (H3K27me3”