Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

By G. M. Cereghetti, A. Stangherlin, O. Brito, Chuang-Rung Chang, C. Blackstone, P. Bernardi, L. Scorrano. Proceedings of the National Academy of Sciences of the United States of America, 2008

1,102 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d7e116f8019e42edb083c2b41bc519b1f734e7db

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Citations in the corpus

Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease (2012, background): “Mitochondrial depolarization, which may occur via sustained cytosolic Ca2+ increases, also causes significant mitochondrial fragmentation, presumably due to phosphorylation of DLP1 [52,53].”
Impaired Balance of Mitochondria Fission and Fusion in Alzheimer Disease (2009, background): “…fission activity: whereas there is still debate over whether phosphorylation of DLP1 at Ser637 enhances or inhibits mitochondrial fission activity (Cereghetti et al., 2008; Han et al., 2008), it appears that phosphorylation of DLP1 at Ser 616 activates mitochondrial fission activity (Taguchi et…”
Mitochondrial dynamics in mammalian health and disease. (2009, background): “Nevertheless, these and a third report showed that this phosphorylation reduces mitochondrial fission, as also demonstrated by the overexpression of phosphomimetic mutants of DRP1 (S637/656D), which markedly elongate mitochondrial filaments (47, 48, 68).”
Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency (2013, background): “Mitochondrial fission is regulated by the cytoplasmic dynamin-related protein 1 that, upon calcineurindependent dephosphorylation, translocates to mitochondria (Yoon et al., 2001; Smirnova et al., 2001; Cereghetti et al., 2008).”
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure (2013, background): “, 2005) and FCCP promoted Drp1 recruitment (Cereghetti et al., 2008).”
Metabolic regulation of mitochondrial dynamics (2016, background): “Phosphorylation at S637 is counteracted by the phosphatases calcineurin (Cribbs and Strack, 2007; Cereghetti et al., 2008) and PP2A/Bβ2 (Dickey and Strack, 2011).”
Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission (2013, background): “Phosphorylation of Drp1 at S637 has been shown to negatively regulate Drp1 function (Chang and Blackstone, 2007; Cribbs and Strack, 2007; Cereghetti et al., 2008).”
Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation (2011, background): “Conversely, phosphorylation of Drp1 at S637 by PKA decreases fission by causing Drp1 retention in the cytosol, whereas dephosphorylation of S637 by calcineurin causes Drp1 translocation to the mitochondria and increased mitochondrial fission (11, 15).”
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy (2009, background): “(13) have reported that mitochondrial depolarization also can stimulate the translocation of the fission protein Drp1 from the cytosol to the mitochondria through a calcineurindependent mechanism.”
Mechanisms of mitochondrial fission and fusion. (2013, background): “It has been suggested that calcium release from depolarized mitochondria may activate Calcineurin (Cribbs and Strack 2007; Cereghetti et al. 2008), whereas apoptosis-induced fission may rely on calcium release from the ER (Scorrano et al.”