Increased hippocampal neurogenesis in Alzheimer's disease

By K. Jin, A. Peel, X. Mao, Lin Xie, B. Cottrell, D. Henshall, D. Greenberg. 2003

1,024 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Genetics, Physiology

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Citations in the corpus

Human Hippocampal Neurogenesis Persists throughout Aging (2018, neutral): “Although we detected some DCX+ processes, they were rarely seen in adult human INPs (Figures 3A–3C and S1D; Video S2), as expected based on previous reports (Jin et al., 2004; Knoth et al., 2010).”
Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells (2006, background): “In addition, there have been recent reports of increased neurogenesis in Alzheimer’s disease, as well as in a transgenic model of Alzheimer’s disease (Jin et al. 2004a,b).”
Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer’s Disease (2009, neutral): “Earlier studies showed that the number of immature neural progenitor cells expressing doublecortin and Neuro-D was increased in other hAPP transgenic lines (Gan et al., 2008; Jin et al., 2004a) and in AD (Jin et al., 2004b).”
Doublecortin expression levels in adult brain reflect neurogenesis (2005, background): “In human AD patients, increased hippocampal neurogenesis was reported to occur in the dentate gyrus (Jin et al., 2004).”
Classification and basic pathology of Alzheimer disease (2009, background): “More recently, signs of neurogenesis, taking place normally in the paraventricular zone and in the dentate gyrus of adults, have been studied in AD with controversial results: markers of neurogenesis have been found to be increased [171]; however, it is suspected that newly generated neurons do not ”
Granule cell dispersion is not accompanied by enhanced neurogenesis in temporal lobe epilepsy patients. (2007, background): “DCX is an established marker for newly generated neurons in the subgranular zone of the adult rodent and human dentate gyrus (Brown et al., 2003; Rao and Shetty, 2004; CouillardDespres et al., 2005; Jin et al., 2004).”
The role of adult hippocampal neurogenesis in brain health and disease (2018, background): “reported that adult hippocampal neurogenesis is increased in AD patients [110].”
Antidepressants increase neural progenitor cells in the human hippocampus (2009, methodology): “Then avidin and biotin were blocked using an Avidin/Biotin blocking kit (Vector SP-2001, Vector Laboratories, Jin et al, 2004) and immunocytochemistry for the second marker was performed with the same method described, but with 0.05% DAB to yield a brown precipitate.”
Molecular mechanisms of neurodegeneration in Alzheimer's disease. (2010, result): “Although there are some controversies over whether neurogenesis is increased (54) or decreased (17,18) in the pathogenesis of AD, more recent studies suggest that apparent increases in markers of neurogenesis in the brains of AD patients may be related to glial and vasculature-associated changes (17”
Neurodegenerative disease and adult neurogenesis (2011, background): “…hippocampal neurogenesis was increased in patients with AD, as shown by an increase in protein expression of DCX and polysialylated-neural cell adhesion molecule (PSANCAM), TOAD-64/Ulip/CRMP (TUC-4), and neurogenic differentiation (NeuroD) in Western blots from AD hippocampus (Jin et al., 2004b).”
Adult hippocampal neurogenesis and its role in Alzheimer's disease (2011, background): “The authors hypothesized that facilitation of neurogenesis might be a self-compensating mechanism to replace the lost neurons and that stimulating hippocampal neurogenesis might provide a new treatment strategy for AD [51].”
Ageing and neuronal vulnerability (2006, background): “, although evidence for a compensatory increase in neurogenesis in AD has also been reporte”
Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous transplantation in the rat. (2005, background): “NSCs continue to produce new neurons throughout life in the subventricular zone (SVZ) and dentate gyrus (DG) of hippocampus in the normal adult mammalian brain (Gage, 2000), and this process of neurogenesis is amplified under pathological conditions (Jin et al., 2001, 2004).”