Doublecortin expression levels in adult brain reflect neurogenesis

By S. Couillard-Després, Beate Winner, S. Schaubeck, R. Aigner, M. Vroemen, N. Weidner, U. Bogdahn, Jürgen Winkler, H. Kuhn, L. Aigner. European Journal of Neuroscience, 2005

978 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Genetics

View Paper: https://www.semanticscholar.org/paper/28d0ad34f18c666fcd3102ee68e5b1cdb7d6676e

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Citations in the corpus

Murine Features of Neurogenesis in the Human Hippocampus across the Lifespan from 0 to 100 Years (2010, background): “A central phase during this development is associated with the expression of doublecortin (DCX) [18,19,20].”
Krüppel-Like Factor 9 Is Necessary for Late-Phase Neuronal Maturation in the Developing Dentate Gyrus and during Adult Hippocampal Neurogenesis (2009, background): “…(Brandt et al., 2003; Hodge et al., 2008), it is expressed in all young adult-born neurons between 3 and 21 d of age, during which they elaborate their dendrites in the molecular layer of the DG and integrate into the hip- pocampal circuit (Couillard-Despres et al., 2005; Espósito et al., 2005).”
Neurogenesis in the Adult Hippocampus. (2015, neutral): “development (Brandt et al. 2003; Rao and Shetty 2004; Couillard-Despres et al. 2005; Plumpe et al. 2006).”
Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis (2011, background): “By using DCX to analyze the levels of neurogenesis (26), we found a substantial reduction of newborn neurons after shRNAmediated Prox1 knockdown compared with animals injected with nontargeting shRNA-expressing control virus (Fig.”
In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. (2007, background): “DCX has been shown to serve as a marker for neuronal precursors, and the number of DCX + cells is positively correlated with the level of adult neurogenesis (Couillard-Despres et al., 2005).”
Persistent Production of Neurons from Adult Brain Stem Cells During Recovery after Stroke (2006, background): “Dcx is a reliable marker of neurogenesis, which is transiently expressed (for about 2–3 weeks) in newly formed neuroblasts [ 20 , 24].”
Granule cell dispersion is not accompanied by enhanced neurogenesis in temporal lobe epilepsy patients. (2007, background): “proliferation activity, but DCX is exclusively expressed in neuronal progenitor cells which are committed to become granule cells (Brown et al., 2003; Rao and Shetty, 2004; Couillard-Despres et al., 2005).”
In contrast to many other mammals, cetaceans have relatively small hippocampi that appear to lack adult neurogenesis (2013, background): “2011), it has been established that DCX immunolabelling of granule cells of the dentate gyrus is a good proxy for the presence of adult hippocampal neurogenesis (Rao and Shetty 2004; Couillard-Despres et al. 2005).”
Reversible effect of X‐irradiation on proliferation, neurogenesis, and cell death in the dentate gyrus of adult mice (2007, positive): “…a single low dose at a low dose-rate, and analyzed proliferation and neurogenesis using endogenous markers for proliferation (Ki67: Kee et al., 2002; Scholzen and Gerdes, 2000) and dividing and differentiating cells of neuronal lineage (doublecortin: Couillard-Despres et al., 2005; and NeuroD: Lee,”
Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain (2009, background): “…(1:200, Accurate), mouse anti-BrdU (1:100, BD), goat anti-NeuroD (Liu et al., 2000) (1:100, Santa Cruz Biotechnology), goat anti-doublecortin (Couillard-Despres et al., 2005) (1:200, Santa Cruz Biotechnology), mouse anti-NeuN (1:100, Millipore Bioscience Research Reagents), rabbit anti-Ki67…”
Epigenetic Modulation of Seizure-Induced Neurogenesis and Cognitive Decline (2007, background): “…proliferating progenitors (using Ki67 as a marker of cycling cells) (Gerdes et al., 1983; Kee et al., 2002) for their coexpression of DCX, a marker for dividing neuroblasts and immature neurons (Brown et al., 2003; Couillard-Despres et al., 2005; Jessberger et al., 2005) by confocal microscopy.”