Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous transplantation in the rat.
By K. Jin, Yunjuan Sun, Lin Xie, X. Mao, J. Childs, A. Peel, A. Logvinova, Surita Banwait, D. Greenberg. 2005
180 citations recorded by the source corpus.
Cell replacement therapy may have the potential to promote brain repair and recovery after stroke. To compare how focal cerebral ischemia affects the entry, migration, and phenotypic features of neural precursor cells transplanted by different routes, we administered neuronal precursors from embryonic cerebral cortex of green fluorescent protein (GFP)-expressing transgenic mice to rats that had undergone middle cerebral artery occlusion (MCAO) by the intrastriatal, intraventricular, and intravenous routes. MCAO increased the entry of GFP-immunoreactive cells, most of which expressed neuroepithelial (nestin) or neuronal (doublecortin) markers, from the ventricles and bloodstream into the brain, and enhanced their migration when delivered by any of these routes. Transplanted neural precursors migrated into the ischemic striatum and cerebral cortex. Thus, transplantation of neural precursors by a variety of routes can deliver cells with the potential to replace injured neurons to ischemic brain regions.
Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cellular and Molecular Neuroscience
In Developmental Neuroscience
Citations in the corpus
- Adult neurogenesis in brain repair: cellular plasticity vs. cellular replacement (2014, background): “The therapeutic potential of the transplanted stem cells have been validated in various models of diseases and injuries (Shihabuddin et al., 2000; Pluchino et al., 2003; Cummings et al., 2005; Jin et al., 2005).”
- The potential of neural stem cells to repair stroke-induced brain damage (2009, background): “When embryonic mouse NPCs were administered intracerebrally, intraventricularly or intravenously into post-ischemic rats, they migrated into the ischemic striatum and cerebral cortex and expressed neuroepithelial or neuronal markers such as nestin and NeuN [ 41 ].”