Adult hippocampal neurogenesis and its role in Alzheimer's disease

By Yangling Mu, Fred H. Gage. Molecular Neurodegeneration, 2011

992 citations recorded by the source corpus.

The hippocampus, a brain area critical for learning and memory, is especially vulnerable to damage at early stages of Alzheimer's disease (AD). Emerging evidence has indicated that altered neurogenesis in the adult hippocampus represents an early critical event in the course of AD. Although causal links have not been established, a variety of key molecules involved in AD pathogenesis have been shown to impact new neuron generation, either positively or negatively. From a functional point of view, hippocampal neurogenesis plays an important role in structural plasticity and network maintenance. Therefore, dysfunctional neurogenesis resulting from early subtle disease manifestations may in turn exacerbate neuronal vulnerability to AD and contribute to memory impairment, whereas enhanced neurogenesis may be a compensatory response and represent an endogenous brain repair mechanism. Here we review recent findings on alterations of neurogenesis associated with pathogenesis of AD, and we discuss the potential of neurogenesis-based diagnostics and therapeutic strategies for AD.

Subfields: Developmental Neuroscience, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/475274fd477632da62cf75e2cd61b3e8e8ac3c1a

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Citations in the corpus

What is normal in normal aging? Effects of Aging, Amyloid and Alzheimer’s Disease on the Cerebral Cortex and the Hippocampus (2014, background): “For instance, neurogenesis in the hippocampus may be important for structural plasticity and network maintenance, and it has been suggested that altered neurogenesis in the hippocampus is an early critical event in AD (Mu and Gage, 2011).”
Residual and plain convolutional neural networks for 3D brain MRI classification (2017, background): “These areas are blurry, but the spots with the highest attention seem to match with the ones most affected by the Alzheimer’s Disease, mainly hippocampus [12] and ventricles [13].”
Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response (2018, background): “Hippocampus plays a critical role in learning and memory processes (Shen et al., 1994; Mu and Gage, 2011) and regional measures of hippocampal atrophy, are one of the strongest predictors of Alzheimer’s disease (AD) progression (Henneman et al.”
Induced Adult Neurogenesis plus BDNF Mimicks the Effects of Exercise on Cognition in an Alzheimer’s Mouse Model (2018, methodology): “Right graph: mean error number in memory retention trial (F(3,41) = 5.”
Blood-Brain Barrier Breakdown in the Aging Human Hippocampus (2015, positive): “We found an age-dependent BBB breakdown in the hippocampus, a region involved in learning and memory (Squire, 1992) that is damaged early in AD (Braak et al., 1993; Mu and Gage, 2011; Whitwell et al., 2012).”
Domain Adaptation for Medical Image Analysis: A Survey (2021, neutral): “For instance, brain structural changes caused by AD usually locate in a limited number of ROIs in structural MRIs, such as hippocampus [144] and ventricles [145].”