Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

By N. Mizushima, Akiko Kuma, Yoshinori Kobayashi, A. Yamamoto, M. Matsubae, Toshifumi Takao, Tohru Natsume, Y. Ohsumi, T. Yoshimori. Journal of Cell Science, 2003

811 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology

View Paper: https://www.semanticscholar.org/paper/d2fd7c101b19f2aeb259d33a358aa80d36256f43

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Citations in the corpus

The genetics and immunopathogenesis of inflammatory bowel disease (2008, background): “The ATG16L1 protein is comprised of an N-terminal APG16 domain that consists of coiled-coil domains and eight C-terminal WD repeat”
Guidelines for the use and interpretation of assays for monitoring autophagy (2012, background): “16).(400,401) Endogenous ATG5, ATG12 or ATG16L1 puncta formation can be followed to monitor autophagy upregulation.”
Protein turnover via autophagy: implications for metabolism. (2007, background): “Atg5 binds Atg16 noncovalently (69, 70), and the tetramerization of Atg16 results in the formation of a large complex (55, 69).”
Autophagy: process and function. (2007, background): “Atg16L is one of two Atg16 homologs and interacts with the Atg12–Atg5 conjugate that is essential for autophagosome formation (Mizushima et al. 2003).”
Hierarchy of Atg proteins in pre‐autophagosomal structure organization (2007, background): “In this context, dot structures labeled with Atg5p, Atg12p and Atg16p could be defined as the PAS in mammalian cells ( Mizushima et al. 2001, 2003 ).”
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages (2009, background): “Atg16L is involved in autophagosome formation, and transiently associates with the surface of forming autophagosomes (isolation membranes); therefore, dot structures observed by Atg16L immunofluorescence represent sites of autophagosome formatio”
Autophagy: molecular machinery for self-eating (2005, background): “In mammalian cells, however, the complex is clearly associated with the forming autophagosome, termed the phagophore or isolation membrane.(64,58) These results lead us to suggest that during the membrane formation stage the Atg12–Atg5-Atg16 com-”
WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1 (2014, background): “identified the domains of Atg16L1, which bind Atg5 (Mizushima et al., 2003) and Rab33b (Itoh et al.”
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1 (2007, background): “The interaction partner of this domain has not yet been identified experimentall”
LC3 conjugation system in mammalian autophagy (2004, neutral): “…Tsukada, Wada, & Ohsumi, 1997; Mizushima, Sugita, Yoshimori, & Ohsumi, 1998; Mizushima, Noda, & Ohsumi, 1999; Mizushima, Yoshimori, & Ohsumi, 2002; Mizushima et al., 2003; Okazaki et al., 2000; Sagiv, Legesse-Miller, Porat, & Elazar, 2000; Scherz-Shouval, Sagiv, Shorer, & Elazar, 2003; Shintani…”
The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. (2008, methodology): “Gel filtration analysis was performed as previously described (Mizushima et al., 2003).”
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. (2009, background): “Indeed, GFP-Atg13 almost completely colocalized with Atg16L1, an isolation membrane marker (Mizushima et al., 2003), confirming that Atg13 localizes to isolation membranes (Figure 2B).”