Hierarchy of Atg proteins in pre‐autophagosomal structure organization

By Kuninori Suzuki, Y. Kubota, T. Sekito, Y. Ohsumi. Genes to Cells, 2007

739 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology

View Paper: https://www.semanticscholar.org/paper/e6577e24db6895ff867484fa24ec7ff96f867ccf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. D. Klionsky
2. N. Mizushima
3. Y. Ohsumi
4. Zhifen Yang
5. I. Slaninová
6. T. Yoshimori
7. T. Johansen
8. M. Komatsu

In Epidemiology

1. D. Klionsky
2. N. Mizushima
3. I. Slaninová
4. Beth Levine
5. Y. Ohsumi
6. T. Johansen
7. Zhifen Yang
8. T. Lamark

Citations in the corpus

• Mechanisms of Autophagy Initiation (2017, background): “Atg17, along with its accessory proteins Atg29 and Atg31, is the first protein to arrive at the PAS is yeast (61), which set the stage for the recruitment of Atg13 and Atg1 as described above.”
• Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation (2010, background): “G361 cells were obtained Atg18 has been shown to move to the PAS in a complex with Atg2,(42) and this relocalization requires the activity of the Atg1 kinase complex and the autophagy specific Vps34 lipid kinase complex.(2) Atg18 can bind PtdIns3P and PtdIns3,5P 2 .”
• The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. (2008, background): “Yeast genetic studies showing a reciprocal dependence of PAS localization of the Atg12 system and Atg8 can be explained by our model (Suzuki et al., 2007).”
• mTOR regulation of autophagy (2010, background): “Atg17 is an essential factor for the PAS localization of Atg1 and several other autophagy components [56,57].”
• Atg32 is a mitochondrial protein that confers selectivity during mitophagy (2009, background): “In the atg1Δ strain, most of the Atg proteins and the Cvt complex are recruited to the PAS (Suzuki et al., 2007), but later steps in the autophagic process are blocked.”
• Autophagy: process and function. (2007, background): “A recent systematic analysis showed that the AP-Atg proteins depend on each other for recruitment to the PAS (Suzuki et al. 2007); in particular, Atg17 was found to be a scaffold for PAS organization (Fig.”
• An Overview of the Molecular Mechanism of Autophagy (2009, background): “Although the role of the PAS is not fully understood, one model suggests that the PAS serves to facilitate the nucleation and/or expansion of the phagophore, the precursor of the autophagosome, through recruitment of Atg proteins (Mizushima et al. 2001; Suzuki et al. 2007).”
• Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy (2013, background): “These processes are coordinated by ATG proteins; among them the ULK1 and Vps34 complexes are well known to function as important regulators in autophagy initiation and progression (Nakatogawa et al., 2009; Suzuki et al., 2007).”
• Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors. (2020, background): “phagophore assembly site (PAS)where the complexes of the core autophagy apparatus congregate [9].”
• Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. (2009, background): “, 2000), and 3) PAS targeting of Atg1 is mildly affected in atg13, whereas in the atg1 mutant PAS targeting of Atg13 is enhanced (Suzuki et al., 2007).”
• Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks (2011, background): “It turned out that most of these Atg proteins are recruited to a single preautophagosomal structure (PAS) in a hierarchical manner upon starvation (97, 98).”