Orientation of Asymmetric Stem Cell Division by the APC Tumor Suppressor and Centrosome

By Y. Yamashita, D. L. Jones, M. Fuller. Science, 2003

789 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/d2fd7ae0eb6121e4b19417425088b9bb4cb0af9f

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Citations in the corpus

An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control (2014, background): “The daughter cell closest to the hub cell remains a stem cell, whereas the distal cell invariably differentiates; this asymmetric division is oriented by the Wnt signaling component APC (79).”
Cadherins in development: cell adhesion, sorting, and tissue morphogenesis. (2006, positive): “Maintenance of the GSC population requires the proper orientation of the division plane, which is determined by cadherin-dependent adhesion between GSCs and the “hub,” a cluster of somatic cells (Yamashita et al. 2003).”
GSK3 signaling in neural development (2010, background): “APC plays a key part in asymmetric stem cell division by anchoring one daughter cell in a specific niche so that it retains self-renewal capacit”
Socializing with the neighbors: stem cells and their niche. (2004, background): “…in Figures 1A, 1B in Yamashita et al., Science 301, 1547-1550, 2003; copyright 2003 AAAS]. role for these junctions in orienting the spindle poles to fates of the two daughter cells become distinct (Figure 4A).permit asymmetric cell divisions (Yamashita et al., 2003 and references therein).”
Stem cells and cancer: two faces of eve. (2006, background): “…niche, whereas the other daughter is displaced away from the Cell 124, M niche and activates expression of genes that launch this cell along the differentiation pathway (Chen and McKearin, 2003; Kiger et al., 2000, 2001; Tulina and Matunis, 2001; Xie and Spradling, 2000; Yamashita et al., 2003).”
Cancer stem cells: models and concepts. (2007, neutral): “[36].”
Stem cell niche: structure and function. (2005, background): “As development proceeds, the need for organogenesis arises, and the embryo proper forms germ line stem cells (GSCs) for reproduction and somatic stem cells (SSCs) for organogenesis.”
No place like home: anatomy and function of the stem cell niche (2008, background): “Second, the particular spatial relationship between stem cells and support cells can polarize stem cells within the niche to promote asymmetric stem cell division”
Centrioles, centrosomes, and cilia in health and disease. (2009, background): “are also compromised when centrosome function is perturbed (Yamashita et al., 2003).”
Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “When the normal spindle orientation in GSCs is disrupted, daughter cell fates are frequently altered (Yamashita et al., 2003).”