Cadherins in development: cell adhesion, sorting, and tissue morphogenesis.
By Jennifer M. Halbleib, W. Nelson. Genes & Development, 2006
1,092 citations recorded by the source corpus.
Tissue morphogenesis during development is dependent on activities of the cadherin family of cell-cell adhesion proteins that includes classical cadherins, protocadherins, and atypical cadherins (Fat, Dachsous, and Flamingo). The extracellular domain of cadherins contains characteristic repeats that regulate homophilic and heterophilic interactions during adhesion and cell sorting. Although cadherins may have originated to facilitate mechanical cell-cell adhesion, they have evolved to function in many other aspects of morphogenesis. These additional roles rely on cadherin interactions with a wide range of binding partners that modify their expression and adhesion activity by local regulation of the actin cytoskeleton and diverse signaling pathways. Here we examine how different members of the cadherin family act in different developmental contexts, and discuss the mechanisms involved.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/07fa4b68278bccfd52381480024fe5ef28c6cc02
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Citations in the corpus
- Tight junctions/adherens junctions: basic structure and function. (2007, background): “Inactivation of different cadherins in a variety of organisms have shown their importance in tissue morphogenesis (Gumbiner, 2005; Halbleib and Nelson, 2006).”
- Repression of E-cadherin by the polycomb group protein EZH2 in cancer (2008, background): “The interaction between these molecules regulate the cell–cell adhesion (Halbleib and Nelson, 2006).”
- Adherens junctions: from molecules to morphogenesis (2010, background): “Molecules of the cadherin superfamily are premetazoan (2), but classic”
- Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. (2007, background): “The fact that Fat may interact with another protocadherin, Dachsous, at the cell surface (Matakatsu and Blair 2004; Halbleib and Nelson 2006) suggests an exciting possibility that the Hippo pathway may be involved in cell growth regulation in response to cell–cell contact.”