Stem cells and cancer: two faces of eve.

By M. Clarke, M. Fuller. Cell, 2006

942 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7a330eb80589dff12065137a7abb4382926f2c00

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In Oncology

Citations in the corpus

MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer (2015, background): “In fact, it seems that each tumor, being either hematologic or solid, includes a minor population of CSCs, capable of tumor initiation [129].”
Cancer stem cells: models and concepts. (2007, background): “This simple observation suggests that tumors are not mere monoclonal expansions of cells but might actually be akin to “abnormal organs,” sustained by a diseased “cancer stem cell” (CSC) population, which is endowed with the ability to self-renew and undergo aberrant differentiation (1, 2).”
Molecular definition of breast tumor heterogeneity. (2007, background): “Putative cancer stem cells have been purified from various human tumor types, frequently using cell surface markers specific for the normal stem cells of the same organ (Clarke and Fuller, 2006; Lynch et al., 2006; Polyak and Hahn, 2006; Weissman, 2005; Wicha et al., 2006).”
Stems cells and the pathways to aging and cancer. (2008, background): “Many cancers including colon, breast, brain, head and neck, pancreatic, and hematopoietic malignancies contain minor populations of tumor-initiating cells or cancer stem cells (CSCs) (reviewed in Clarke and Fuller, 2006).”
A perivascular niche for brain tumor stem cells. (2007, background): “Alternatively, deregulation of extrinsic factors within the niche might lead to uncontrolled proliferation of stem cells and tumorigenesis (Clarke and Fuller, 2006).”
Colorectal Cancer Stem Cells Are Enriched in Xenogeneic Tumors Following Chemotherapy (2008, background): “Unlike in normal development, however, neoplastic progenitor cell populations can gain self-renewal capabilities, thereby also fulfilling the definition of a CSC [2,3].”
Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. (2011, background): “Because the endosteal HSC niche plays a crucial role in maintaining stemness, the ability of tumor cells to engage the endosteal HSC niche may facilitate the ability of tumor cells to establish metastatic foci in bone while remaining dormant over long time periods (33, 34).”
A Myc rather than core pluripotency module accounts for the shared signatures of embryonic stem and cancer cells (2010, neutral): “between Embryonic Stem and Cancer”
DNA methylation: superior or subordinate in the epigenetic hierarchy? (2011, background): “This theory is based on a number of observations: tumors harbor rare cells expressing stem/ precursor markers, tumors are heterogeneous with only a subset of cells possessing tumor regeneration capacity, and many pathways important to the maintenance of stem/precursor cells are upregulated, mutated,”
Making a tumour's bed: glioblastoma stem cells and the vascular niche (2007, background): “These stem-cell-like cancer cells make up just a small fraction of the malignant cells in leukaemias and many solid tumours, but they are solely responsible for propagating the disease in laboratory model”
Combination therapy in combating cancer (2017, background): “CAIX overexpression is correlated with poor prognosis partly because these cells are highly enriched in stemness properties [73-75]; in vivo testing has demonstrated that stem cell regulation is highly dependent on pH regulation [76].”
The biology of cancer stem cells. (2007, background): “hematopoietic stem cell stem cell theory, cancer stem cells can also be derived from a progenitor cell that gives rise to self-renewing cancer stem cells, which are capable of generating self-renewing as well as non-self-renewing progeny (Clarke & Fuller 2006, Reya et al. 2001).”
A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing (2007, neutral): “dtd" [ ]> Adult cancers may derive from stem or early progenitor cell”
Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy (2008, positive): “Examples of such tissue homeostasis are provided by the mammalian hematopoietic and digestive systems, in which millions of differentiated blood and epithelial cells expire daily, only to be replaced by the fresh division progeny of resident stem cells (Clarke and Fuller, 2006; Reya and Clevers, 200”
The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. (2009, background): “in Mammary Stem Cells”