An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

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Modeling Development and Disease with Organoids. (2016, background): “As first described for gut stem cells (Korinek et al., 1998), the Wnt pathway has emerged as the major driver of epithelial aSCs (Clevers et al., 2014).”
Wnt signaling in development and tissue homeostasis (2018, background): “The best-characterized function of Wnt signaling in adult tissues is in the maintenance of stem cell niches, where Wnt ligands promote the proliferation and self-renewal capability of tissue-specific stem cells (Clevers et al., 2014).”