Stem cell niche: structure and function.

By Linheng Li, T. Xie. 2005

1,282 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology, Public Health, Environmental and Occupational Health

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “In the past decades, significant progress has been made in describing stem cell niches at cellular, molecular, and functional levels in several model systems, including Drosophila germ line, mammalian skin, intestines , and bone marrow (reviewed by Li and Xie, 2005; Morrison and Spradling, 2008).”
The Ecological Niche: History and Recent Controversies (2015, background): “It has a functional dimension (Li and Xie 2005 : 622; Scadden 2006 : 1078).”
Muscle satellite cells and endothelial cells: close neighbors and privileged partners. (2007, background): “Post-injury muscle regeneration is associated with an increase in both capillarisation and cross-sectional area of individual regenerating myofibers (Luque et al., 1995).”
Stem Cell Niche (2013, methodology): “While fi broblastlike stromal cells are best appreciated in in vitro cultures where they proliferate luxuriantly in serum-rich medium to form adherent layers, they are more diffi cult to defi ne in vivo due to (1) their much smaller numerical proportion in comparison to the rapidly proliferating hem”
Oxygen in stem cell biology: a critical component of the stem cell niche. (2010, background): “HSCs share an important relationship with osteablasts and other stromal elements of the bone marrow niche critical to their maintenance and protection (Jones and Wagers, 2008; Li and Xie, 2005; Qian et al., 2007; Yoshihara et al., 2007).”
BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “, immunomodulatory substances, neurotrophic growth factors, and stem cell regulators), some of which are constitutively expressed by NPCs for maintaining tissue homeostasis both during development and adult life (127).”
Extracellular matrix: a dynamic niche component during cancer progression (2012, positive): “Such an anchorage physically con strains stem cells to make direct contact with niche cells, which produce paracrine signaling molecules that are essential for maintaining stem cell properties (Fig. 2 A, stage 1; Li and Xie, 2005).”
Brain micro-ecologies: neural stem cell niches in the adult mammalian brain (2008, background): “123 follicle and nervous system has revealed common and unique features (figure 1; reviewed in Spradling et al. 2001; Doetsch 2003b; Fuchs et al. 2004; Li & Xie 2005).”
Spermatogenesis in fish. (2010, background): “The niche is defined by its specific microenvironment that allows the stem cell to retain its stemness (Hofmann, 2008; Li and Xie, 2005).”
Normal stem cells and cancer stem cells: the niche matters. (2006, background): “In adults, stem cells reside in a physiologically limited and specialized microenvironment, or niche, that supports stem cells but varies in nature and location depending on the tissue type (16, 17 ).”
The therapeutic potential of neural stem cells (2006, background): “This milieu contains molecules (such as immunomodulatory substances, neurotrophic growth factors and stem cell regulators) that are constitutively expressed by neural stem cells for the maintenance of tissue homeostasis, both during development and in adulthoo”
Extracellular matrix dynamics in development and regenerative medicine (2008, background): “It is now generally assumed that stem cell niches exist in all adult tissues; however, the exact locations have only been defined in a few tissues (Li and Xie, 2005).”