Cancer stem cells: models and concepts.

By Piero Dalerba, Robert W. Cho, M. Clarke. Annual Review of Medicine, 2007

1,338 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/6bb0c8002c9d232cdef765cc63e2d2f540a938bd

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Citations in the corpus

Modelling breast cancer: one size does not fit all (2007, background): “Tumour-initiating cells are proposed to be more resistant to therapy and lead to disease recurrence and metastasis; evidence is accumulating to support this hypothesi”
let-7 regulates self renewal and tumorigenicity of breast cancer cells. (2007, background): “According to the hypothesis, T-IC are not only the source of the tumor but also may be responsible for tumor progression (Dalerba et al., 2007), metastasis (Wicha, 2006), resistance to therapy, and subsequent tumor recurrence (Al-Hajj, 2007).”
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs (2009, background): “In the cancer stem cell concept, some cancer cells maintain typical stemness properties, including the capacity to self renew, proliferate and differentiate, and are thought to be crucial for the initiation and maintenance of tumours as well as their metastase”
Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity (2008, background): “R evidence suggests that various, if not all, tumors consist of heterogeneous populations of cells differing in marker expression and growth capacities (1, 2).”
Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. (2007, background): “CSC are likely to undergo symmetric and asymmetric divisions in vivo, which results in the expansion of the tumorigenic cell population while producing a progeny of more differentiated cells that constitute the prevalent population of the tumor cell mass (Dalerba et al., 2007).”
Single-cell dissection of transcriptional heterogeneity in human colon tumors (2011, background): “For example, although it has been postulated that multilineage differentiation can contribute to tumor heterogeneit”
Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment (2018, background): “Although CSC model explains the heterogeneity of cancers in terms of hierarchical structure and progression mode, the origins of CSCs are currently unclear and controversial [36, 37].”
Signal transduction by focal adhesion kinase in cancer (2009, background): “A major conceptual advance in cancer research in recent years is the proposed role of cancer stem cells in the initiation and progression of various cancers [168, 169].”