Hypoxia signalling in cancer and approaches to enforce tumour regression

By J. Pouysségur, Frédéric Dayan, N. Mazure. Nature, 2006

1,720 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5bbdcf74ee4cdf263a532b6dbae0b8dd5efb9722

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Citations in the corpus

Interfering with pH regulation in tumours as a therapeutic strategy (2011, background): “In addition, H + ions are directly extruded from the cells, either in exchange for other cations (such as Na + ) or by means of the vacuolar ATPase (V-ATPase”
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer (2009, background): “This study reinforced the idea that manipulating hypoxic tumour metabolism by targeting specific HIFinduced glycolytic enzymes could participate in bringing about a metabolic deficiency through an indirect block in ATP production [10, 123].”
Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. (2016, background): “The affinity of PHDs and FIH-1 for oxygen differs and, since FIH-1 has a higher affinity (lower Km) for oxygen, PHDs are thought to be more rapidly inhibited in low oxygen conditions (Pouyssegur et al., 2006).”
Hypoxia-induced autophagy: cell death or cell survival? (2010, background): “Why would an apoptotic gene be fully induced by HIF in conditions where HIF induces a cell survival response? We thus questioned its function in a hypoxic tumor environment and demonstrated, for the first time, that rapid and full induction of BNIP3 could instead protect from cell death through an a”
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction (2009, neutral): “Consequently many tumors upregulate the transcription factor hypoxia-inducible factor HIF-1 (Pouyssegur et al., 2006).”
Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α (2009, background): “Although hypoxia may be an inevitable outcome of the rapidly growing tumor outstripping its vascular supply, it confers certain advantages on tumor cells (Pouyssegur et al., 2006).”
Hypoxia and cancer (2007, background): “synthesis, allowing for cellular adaptation and subsequent survival [12].”
Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment (2009, neutral): “Under these conditions, gene expression is altered to facilitate adaptation and survival in hypoxia (89).”
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the pre-metastatic niche (2009, background): “Increased metastases, enhanced tumor progression, and decreased patient survival have been associated with primary tumors that contain large numbers of poorly oxygenated (hypoxic) tumor cells (Cairns et al., 2003; Hockel and Vaupel, 2001; Pouyssegur et al., 2006).”
Tumor microenvironment abnormalities: Causes, consequences, and strategies to normalize (2007, background): “There are at least two sources of Hþ ions in tumors—lactic acid and carbonic acid [Helmlinger et al., 2002; Pouyssegur et al., 2006].”
Oxygen in stem cell biology: a critical component of the stem cell niche. (2010, background): “Hypoxic microenvironments within tumors have long been appreciated to be a product of aberrant vasculature and due to a rapidly dividing tumor mass that outstrips its vascular supply (Figure 2) (Carmeliet and Jain, 2000; Pouyssegur et al., 2006).”