The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis

By Jiyong Liang, Shan H. Shao, Zhi-xiang Xu, Bryan T. J. Hennessy, Z. Ding, Michelle D. Larrea, S. Kondo, D. Dumont, J. Gutterman, C. Walker and 2 more. Nature Cell Biology, 2007

893 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/64edb0c91d39601145019d9bffbbdd3f84dde3ff

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In Epidemiology

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4. Guido Kroemer
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In Molecular Biology

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In Oncology

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Citations in the corpus

• Self-eating and self-killing: crosstalk between autophagy and apoptosis (2007, background): “The LKB1–AMPK pathway-dependent phosphorylation of p27 at Thr198 stabilizes the cyclin-dependent kinase inhibitor p27, which permits cells to survive growth-factor withdrawal and metabolic stress through autophagy instead of undergoing apoptosi”
• Cardiac autophagy is a maladaptive response to hemodynamic stress. (2007, background): “Intriguingly, AMP-activated protein kinase, an ATP sensor that is increased in cardiac hypertrophy (45), is linked with autophagy (46).”
• Autophagy and the integrated stress response (2010, neutral): “…stimulates autophagy, as well as the phosphorylation and activation of p27kip1, a cyclin-dependent kinase inhibitor that leads to cell-cycle arrest (Liang et al., 2007). mTOR inhibition results in autophagy induction, as well as in the inhibition of anabolic reactions including IRES-independent…”
• Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer. (2017, neutral): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript 2007; Hu et al., 2007; Liang et al., 2007; Tibes et al., 2006).”
• An Overview of the Molecular Mechanism of Autophagy (2009, background): “Furthermore, AMPK phosphorylates p27, a cyclin-kinase inhibitor, thereby stabilizing p27, whereas ectopic expression of wild-type or a stabilized p27 mutant induces autophagy (Liang et al. 2007).”
• The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy (2008, background): “Phosphorylation of threonine 198 (Thr198) of p27 by kinases, including AMP-activated protein kinase (AMPK), seems to stabilize p27 in G0 (Ref”
• The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon (2011, neutral): “AMPK can induce autophagy by phosphorylating (Thr198) and stabilizing the cyclin-dependent kinase inhibitor 1B (p27) (Liang et al., 2007).”
• The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis (2011, background): “The role of AMPK in prostate cancer is controversial (Park et al, 2009; Zhou et al, 2009); however, AMPK has an essential energy sensing role in cells and is critical in deter- mining cell fate under stress conditions (Liang et al, 2007).”