Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

By G. Bellot, Raquel García-Medina, P. Gounon, J. Chiche, D. Roux, J. Pouysségur, N. Mazure. Molecular and Cellular Biology, 2009

1,454 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Parasitology

View Paper: https://www.semanticscholar.org/paper/e800e17aed69f13412afc87f3bef7e8a363c321f

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In Epidemiology

1. Beth Levine
2. Guido Kroemer
3. D. Klionsky
4. I. Slaninová
5. N. Mizushima
6. Douglas R. Green
7. V. Deretic
8. L. Galluzzi

In Molecular Biology

1. Guido Kroemer
2. Beth Levine
3. Douglas R. Green
4. I. Slaninová
5. D. Klionsky
6. L. Galluzzi
7. Guillermo Mariño
8. V. Deretic

In Parasitology

1. Beth Levine
2. D. Klionsky
3. Douglas R. Green
4. Guido Kroemer
5. V. Deretic
6. Katherine R Parzych
7. Yongqiang Chen
8. L. Galluzzi

Citations in the corpus

• Autophagy as a target for anticancer therapy (2011, background): “Concomitantly, there is an increase in hypoxia-inducible transcription factor 1α (HIF1α), which promotes autophagy (through BNIP3 [BCL2/adenovirus E1B 19 kDa protein-interacting protein 3] and BNIP3-like protein) and angiogenesis”
• Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. (2016, background): “HIF-1 is directly involved in regulating mitochondrial autophagy by inducing expression of the BH3-only proteins BNIP3 andBNIP3L,whichpromotes release of Beclin-1, a major autophagy regulator (Zhang et al., 2008a; Bellot et al., 2009).”
• Autophagy in malignant transformation and cancer progression (2015, positive): “More-over, the hyperactivation of HIF-1 supports mitophagy upon the upregulation of BCL2/adenovirus E1B 19 kDa interacting protein 3 (BNIP3) and BNIP3-like (BNIP3L) even in normoxic conditions (Tracy et al , 2007; Zhang et al , 2008; Bellot et al , 2009; Wilkinson et al , 2009).”
• Autophagy and the integrated stress response (2010, neutral): “phate shunt and helps to lower intracellular ROS (Bensaad et al., 2009).”
• Cell Death Signaling. (2015, background): “Under stress conditions (e.g., starvation or hypoxia), the BH3-only proteins Bad and Bnip3 release beclin 1 to permit its participation in the autophagic process (Maiuri et al. 2007a,b; Bellot et al. 2009).”
• Mitophagy: mechanisms, pathophysiological roles, and analysis (2012, background): “First, Nix can stimulate the induction of autophagy by dissociating the Bcl-2-Beclin 1 complex through competitively binding to Bcl-2 by means of its BH3 domain (Bellot et al. , 2009 ).”
• The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy (2015, background): “In addition, acute hypoxia was associated with more aggressive tumor phenotype through induction of spontaneous metastasis.(12,21,22)”
• The LIR motif – crucial for selective autophagy (2013, background): “Bnip3 and Nix are both involved in hypoxia-induced mitophagy (Zhang et al., 2008; Bellot et al., 2009).”
• Hypoxia-Inducible Factors in Physiology and Medicine (2012, background): “Studies in cultured cells (Jiang et al., 1996b) and isolated, perfused, and ventilated lung preparations (Yu et al., 1998) revealed an exponential increase in HIF-1a levels at O2 Cell 148, February 3, 2012 ª2012 Elsevier Inc. 399 Under hypoxic conditions, hypoxia-inducible factor 1 (HIF-1) activates”