GRP78 induction in cancer: therapeutic and prognostic implications.

By Amy S. Lee. Cancer Research, 2007

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MYB function in normal and cancer cells (2008, methodology): “and has recently been used as a receptor for the delivery of toxic peptides to cancer cell”
Pathogenesis of mucormycosis. (2012, background): “GRP78 (also known as BiP/HSPA5) was discovered as a cellular protein induced by glucose starvation [47].”
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities (2008, background): “Indeed, various chemical inhibitor approaches to antagonizing the GRP78 protein have been preclinically investigated as possible cancer therapies (reviewed in Ref”
The impact of the unfolded protein response on human disease (2012, background): “Increased expression of BiP/GRP78, which is primarily regulated by ATF6, correlates with chemotherapeutic resistance and is observed in aggressive cancers (Lee, 2007).”
ER chaperones in mammalian development and human diseases (2007, background): “in normal organs has prompted new directions in targeting cytotoxic agents into cancer cells [71,74,90].”