Reduced expression of Dicer associated with poor prognosis in lung cancer patients

By Yoko Karube, Hisaaki Tanaka, H. Osada, S. Tomida, Y. Tatematsu, K. Yanagisawa, Yasushi Yatabe, J. Takamizawa, S. Miyoshi, T. Mitsudomi and 1 more. Cancer Science, 2005

652 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/cd153ea0a05760d6b746c64e37731a21a4b2550c

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Citations in the corpus

MicroRNA signatures in human cancers (2006, background): “This correlated with reduced post-operative survival and poor tumour differentiation status, both of which are associated with a poor prognosi”
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review (2012, neutral): “Finally, loss of Dicer and/or Drosha has also been inversely correlated with outcome in lung cancer (Karube et al, 2005), cancers of the ovarian epithelium (Merritt et al, 2008), and more recently in other tumour types as nasopharyngeal carcinoma (Guo et al, 2012), neuroblastoma (Lin et al, 2010)…”
MicroRNA expression profiling in prostate cancer. (2007, background): “There were also more miRNAs that were up-regulated in hormonerefractory carcinomas (n = 14) than in untreated carcinomas (n = 8). Defects in the miRNA processing machinery that have been detected in cancer samples ( 41 , 42) could explain the overall decreased expression of miRNAs, but also up-regul”
A MicroRNA targeting dicer for metastasis control. (2010, background): “Genetically, as revealed by knockout of Dicer or Drosha in mice, miRNA biosynthesis is essential for basic cellular functions, such as stemness, cell-cycle progression, and mitosis (Bernstein et al., 2003; Fukagawa et al., 2004; Tang et al., 2007); these processes are ostensibly essential at all…”
Many roads to maturity: microRNA biogenesis pathways and their regulation (2009, background): “In addition, reduced expression of Dicer is associated with a poor prognosis in lung cance”
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. (2006, background): “.1016/j.ccr.2006.01.025 189 cancers with a significant prognostic impact on patient survival (Karube et al., 2005).”
MicroRNA and cancer (2012, background): “Importantly, mouse models featuring miRNA overexpression or ablation have demonstrated causal links between miRNAs and cancer development and miRNAs are rapidly entering the clinic as biomarkers and putative therapeutic targets (Iorio and Croce, 2012; Kasinski and Slack, 2011).”
A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. (2005, neutral): “associated with a shortened survival (8).”
Impaired microRNA processing enhances cellular transformation and tumorigenesis (2007, result): “Furthermore, our results are consistent with observations correlating reduced Dicer1 expression in a subset of non–small cell lung cancers with poor prognosi”