MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review

By Marilena V. Iorio, Carlo Maria Croce. EMBO Molecular Medicine, 2012

1,801 citations recorded by the source corpus.

Early studies have shown how aberrantly expressed microRNAs are a hallmark of several diseases like cancer. MicroRNA expression profiling was shown to be associated with tumour development, progression and response to therapy, suggesting their possible use as diagnostic, prognostic and predictive biomarkers. Moreover, based on the increasing number of studies demonstrating that microRNAs can function as potential oncogenes or oncosuppressor genes, with the goal to improve disease response and increase cure rates, miRNA‐based anticancer therapies have recently been exploited, either alone or in combination with current targeted therapies. The advantage of using microRNA approaches is based on its ability to concurrently target multiple effectors of pathways involved in cell differentiation, proliferation and survival. Here, we review our current knowledge about the involvement of microRNAs in cancer, and their potential as diagnostic, prognostic and therapeutic tools.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b30a47d8a5027da4d8de41fdfd3607ded2461ce5

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Citations in the corpus

miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients (2016, background): “MicroRNAs (miRNAs) are small non-coding RNA molecules regulating gene expression and widely influencing pathways associated with tumor development, progression, and response to therapy [4].”
In vivo delivery of miRNAs for cancer therapy: Challenges and strategies (2014, background): “Thus, miRNAs can serve as both diagnostic and prognostic biomarkers in cancer [43].”
Breast Cancer—Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies—An Updated Review (2021, background): “Some miRNAs are related to the development, progression, and response of the tumor to therapy [235].”
Circulating Exosomal microRNAs as Biomarkers of Colon Cancer (2014, neutral): “markers [9].”
MicroRNA and cancer (2012, background): “Importantly, mouse models featuring miRNA overexpression or ablation have demonstrated causal links between miRNAs and cancer development and miRNAs are rapidly entering the clinic as biomarkers and putative therapeutic targets (Iorio and Croce, 2012; Kasinski and Slack, 2011).”
MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions (2016, background): “Because of their ubiquitous role in gene regulation, they are involved in many physiological processes, such as differentiation, proliferation, apoptosis and development, and their dysregulation has been related to various pathological disorders, including muscular dystrophy [2], diabetes [3] and se”
MicroRNA (miRNA) in cancer (2015, background): “Mouse models featuring miRNA overexpression or ablation have demonstrated causal links between miRNAs and cancer development [26,27].”
Evolution of the cancer stem cell model. (2014, background): “Epigenetic modiﬁcations of DNA, histones, and nucleosomes as well as noncoding RNAs, including miRNA, allow for modiﬁcation of gene expression (Baylin and Jones, 2011; Iorio and Croce, 2012).”