Impaired microRNA processing enhances cellular transformation and tumorigenesis

By Madhu S. Kumar, Jun Lu, Kim L. Mercer, Todd R. Golub, T. Jacks. Nature Genetics, 2007

1,550 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b9d66b5efb8d0f2d86e6355a9b5f31cfa9598f0b

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Citations in the corpus

MicroRNA Functions in Stress Responses (2010, neutral): “Indeed, such reductions and mutations are commonly observed in tumors (Esquela-Kerscher and Slack, 2006; Kumar et al., 2007; Lu et al., 2005).”
Roles for microRNAs in conferring robustness to biological processes. (2012, positive): “…depleted in tumors relative to their normal tissue counterparts (Lu et al., 2005), and tumor growth is accelerated in models of global miRNA depletion, such as knockdown of components of the miRNA biogenesis pathway (Kumar et al., 2007) or heterozygous deletion of Dicer (Kumar et al., 2009).”
Genetic variants of miRNA sequences and non-small cell lung cancer survival. (2008, background): “Although we are just beginning to understand how this novel class of gene regulators is involved in cancer-related processes, it was shown that miRNA expression profiles could be used to classify human cancers (6), and a global repression of miRNA maturation promoted cellular transformation and tumo”
Many roads to maturity: microRNA biogenesis pathways and their regulation (2009, neutral): “Notably, miRNA processing defects also enhance tumorigenesi”
The mammalian ovary from genesis to revelation. (2009, background): “Potential mechanisms of miRNA deregulation in cancer are diverse and include defects in miRNA processing (638), DNA copy number abnormalities (639–641), epigenetic alterations (641, 642), mutations in the miRNA or its mRNA binding site (643), and aberrant transcription (644).”
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. (2008, positive): “A close link exists between deregulation of developmental programs and tumorigenesis, and a growing body of evidence indicates that altered expression of miRNAs is involved in the pathogenesis of human cancers (Costinean et al., 2006; Croce and Calin, 2005; Esquela-Kerscher and Slack, 2006; Hammond,”
Therapeutic delivery of miR-26a inhibits cancer cell proliferation and induces tumor-specific apoptosis (2009, positive): “, 2005) and that experimental impairment of miRNA processing enhances cellular transformation and tumorigenesis (Kumar et al., 2007).”
MicroRNAs and cancer: short RNAs go a long way. (2009, background): “On the other hand, work with experimental models of lung cancer has shown that genetic or RNAi-based inhibition of miRNA biogenesis can promote tumor formation and progression (Kumar et al., 2007).”
Genomic profiling of microRNA and mRNA reveals deregulated microRNA expression in prostate cancer (2008, background): “Changes to their expression levels can alter cell function and induce cellular transformation (4).”
Widespread microRNA repression by Myc contributes to tumorigenesis (2008, background): “Downregulation of miRNA probably contributes to neoplastic transformation by allowing an increased expression of proteins with oncogenic potentia”