Unique microRNA molecular profiles in lung cancer diagnosis and prognosis.

By N. Yanaihara, N. Caplen, E. Bowman, M. Seike, K. Kumamoto, Ming Yi, R. Stephens, A. Okamoto, J. Yokota, Tadao Tanaka and 4 more. Cancer Cell, 2006

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MicroRNA (miRNA) expression profiles for lung cancers were examined to investigate miRNA's involvement in lung carcinogenesis. miRNA microarray analysis identified statistical unique profiles, which could discriminate lung cancers from noncancerous lung tissues as well as molecular signatures that differ in tumor histology. miRNA expression profiles correlated with survival of lung adenocarcinomas, including those classified as disease stage I. High hsa-mir-155 and low hsa-let-7a-2 expression correlated with poor survival by univariate analysis as well as multivariate analysis for hsa-mir-155. The miRNA expression signature on outcome was confirmed by real-time RT-PCR analysis of precursor miRNAs and cross-validated with an independent set of adenocarcinomas. These results indicate that miRNA expression profiles are diagnostic and prognostic markers of lung cancer.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/39084810b8081be9e7b50d7ab37a6072a33b5963

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Citations in the corpus

A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes (2006, background): “Furthermore, two studies have documented frequent downregulation of let-7 family members in lung cancer with associated poor prognosis (Takamizawa et al., 2004; Yanaihara et al., 2006).”
MicroRNAs in Common Human Diseases (2012, background): “In addition, up-regulation of miR-155 and down-regulation of let-7a were correlated with poor survival of lung cancer patients [47], indicating an imbalance of cell death and proliferation during cancer development [48–50].”
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Modulation of K-ras-dependent lung tumorigenesis by microRNA-21 (2010, positive): “Recently, miR-21 expression levels have proven useful prognostic markers in NSCLC (Markou et al., 2008; Yanai- hara et al., 2006).”
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