MicroRNA signatures in human cancers

By George A. Calin, Carlo Maria Croce. Nature Reviews. Cancer, 2006

7,881 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a7d942a17c29260fe49058c069fda02a5a8eb9e8

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Citations in the corpus

Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening (2009, background): “Studies have shown that profiles of miRNA expression differ between normal tissue and tumour tissues and vary among tumour types.(5) 7 Evidence suggests that miRNA expression profiles can cluster similar tumour types together more accurately than the expression profiles of protein-coding mRNA genes.”
MicroRNA signatures in human ovarian cancer. (2007, methodology): “We used a custom microarray platform already validated by numerous studies (19) to evaluate miRNA expression profiles on a heterogeneous set of ovarian tissues from different patients.”
MicroRNA signature predicts survival and relapse in lung cancer. (2008, methodology): “MicroRNAs can posttranscriptionally regulate the expression of hundreds of their target genes, thereby controlling a wide range of biological functions such as cellular proliferation, differentiation, and apoptosis (Calin and Croce, 2006b).”
MicroRNA silencing for cancer therapy targeted to the tumor microenvironment (2014, background): “4a) and (2) mir-155LSLtTA mice after progression to conspicuous lymphadenopathy (Extended Data”
OncomiRs: the discovery and progress of microRNAs in cancers (2007, background): “Deregulation of oncomiRs is associated with genetic or epigenetic alterations, including deletion, amplification, point mutation and aberrant DNA methylation [7].”
MicroRNAs in body fluids—the mix of hormones and biomarkers (2011, positive): “Paradigms of miRNAs in cancer MiRNAs are altered in every type of cancer Genome-wide miRNA-expression-profiling studies using high-throughput technologies have demonstrated that almost all cancer types present a specific profile of upregulated and downregulated miRNAs”
p53 represses c-Myc through induction of the tumor suppressor miR-145 (2009, background): “It has been reported that miRNAs are frequently deregulated in malignant tissues (11).”
MicroRNAs in stress signaling and human disease (2012, background): “Patterns of miRNA expression provide useful information for tumor classification and prognosis (Calin and Croce, 2006).”