Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body

By M. Giannakou, M. Goss, Martin A. Jünger, E. Hafen, S. Leevers, Linda Partridge. Science, 2004

540 citations recorded by the source corpus.

Subfields: Aging, Endocrine and Autonomic Systems, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c747d008d5e3bce5efa23bea55edf0d05913340b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. C. Kenyon
2. A. Brunet
3. E. L. Greer
4. F. Picard
5. L. Guarente
6. Norbert Perrimon
7. Fabio Demontis
8. D. Sinclair

In Endocrine and Autonomic Systems

1. A. Brunet
2. Norbert Perrimon
3. Fabio Demontis
4. L. Guarente
5. E. L. Greer
6. C. Kenyon
7. R. DePinho
8. Ergun Sahin

In Molecular Biology

1. F. Picard
2. C. Kenyon
3. Dervis A M Salih
4. Norbert Perrimon
5. Markus R. Wenk
6. E. L. Greer
7. L. Guarente
8. A. Brunet

Citations in the corpus

• Calorie restriction--the SIR2 connection. (2005, background): “A recent p tstudy in Drosophila showed that flies with a reduced fat body (which is an analog of mammalian WAT and n ealso liver) live longer than controls (Giannakou et al., 2004).”
• FOXO transcription factors at the interface between longevity and tumor suppression (2005, background): “Interestingly, expression of a wild-type form of dFOXO is sufficient to increase longevity in flies (Giannakou et al., 2004; Hwangbo et al., 2004) and prevent the ageassociated decline of cardiac functions (Wessells et al., 2004).”
• FoxO transcription factors in the maintenance of cellular homeostasis during aging. (2008, background): “In flies, activating dFOXO in the cells of the fat body (the equivalent of mammalian white adipose and liver tissue) also extends lifespan [48,49].”
• FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis During Aging (2010, methodology): “For example, foxo overexpression in the Drosophila fat body extends life span, indicating a key role of this tissue in the regulation of longevity (Giannakou et al., 2004; Hwangbo et al., 2004).”
• The emerging field of lipidomics (2005, background): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5728">PTEN )) activities, in concert with downstream effectors (for example, AKT/PKB), controls cellular growth and cell deat”
• A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. (2006, unknown): “The Drosophila protein dFOXO also promotes life span, suggesting that FOXO function in longevity is conserved across evolution (Giannakou et al., 2004; Hwangbo et al., 2004).”
• The plasticity of aging: insights from long-lived mutants. (2005, background): “A signaling ole for adipose tissue may be conserved since increasng FOXO activity specifically in adipose tissue extends he life spans of flies (Giannakou et al., 2004; Hwangbo t al., 2004), and in worms, increasing FOXO activity in he intestine, which also serves as the animal’s adipose issue,…”