FoxO transcription factors in the maintenance of cellular homeostasis during aging.

By Dervis A M Salih, A. Brunet. Current Opinion in Cell Biology, 2008

625 citations recorded by the source corpus.

Subfields: Aging, Geriatrics and Gerontology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bda87be834b868e7e623e010d9c9954c7b89ef4c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. Hilmar Bading
2. G. Hardingham
3. S. Manolagas
4. Norbert Perrimon
5. A. Brunet
6. Fabio Demontis

In Geriatrics and Gerontology

1. Hilmar Bading
2. G. Hardingham
3. S. Manolagas
4. A. Brunet

In Molecular Biology

1. Hilmar Bading
2. G. Hardingham
3. S. Manolagas
4. Dervis A M Salih
5. H. Chae
6. Atul J. Butte
7. Norbert Perrimon
8. T. Palmer

Citations in the corpus

• Target identification using drug affinity responsive target stability (DARTS) (2009, background): “3E), the Forkhead transcription factor that mediates lifespan extension by the insulin/IGF-1 pathway (19), reminiscent of its requirement for longevity in eIF4G knockdown animals (20).”
• ER stress: Autophagy induction, inhibition and selection (2015, background): “(reviewed in reference.(195)) There are 4 FOXO family members in mammals: FOXO1/FKHR, FOXO3/FKHRL1, FOXO4/AFX, and FOXO6.”
• Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders (2010, positive): “The forkhead box protein O (FOXO) class of transcription factors can promote neuronal death following excitotoxic injury, trophic factor withdrawal and oxidative stres”
• From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. (2010, background): “These changes in turn lead to the activation of FoxOs and thereby to FoxO-mediated OS responses by regulating the transcription of antioxidant enzymes such as MnSOD and catalase as well as genes involved in cell cycle, DNA repair, and lifespan (64, 65).”
• FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis During Aging (2010, background): “The Insulin/IGF-1 signaling pathway has been implicated in the control of aging across evolution via its downstream signaling component FOXO (DAF-16 in C. elegans), a member of the fork-head box O transcription factor family (Salih and Brunet, 2008).”
• FoxO3 regulates neural stem cell homeostasis (2009, positive): “FoxO transcription factors are inactivated in response to insulin or growth factors by phosphorylation by the protein kinase Akt, which results in their nuclear export (Salih and Brunet, 2008).”