Protein Oxidation in Aging and Age‐Related Diseases

By E. Stadtman. Annals of the New York Academy of Sciences, 2001

654 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/c1e6335a3e692e41fdb88489d054daa215340702

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In Clinical Biochemistry

1. J. Post
2. A. Cuervo
3. J. Boonstra
4. F. Collin
5. W. Dröge

In Molecular Biology

1. A. Cuervo
2. J. Post
3. Wangang Zhang
4. D. Ahn
5. J. Boonstra
6. Shan Xiao
7. R. Kiffin
8. F. Collin

In Physiology

1. R. Kiffin
2. J. Post
3. A. Cuervo
4. L. Zuo
5. J. Boonstra
6. Zewen Liu
7. P. Dimitrion
8. Alexander C Ziegler

Citations in the corpus

• Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation (2007, background): “), may be in response to oxidative stress, a common feature of aged cells [”
• Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications (2017, background): “Elderly individuals are more prone to OS, which partially accounts for AD susceptibility in aging populations [45, 49].”
• Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells. (2004, background): “Proteins can be oxidatively modified, resulting in increases in the level of protein carbonyls (Levine, 2002), oxidized methionines (Stadtman and Levine, 2003) and/or cysteines (Stadtman, 2001; Davies, 2000), protein hydrophobicity (Meucci et al.”
• Oxidative Stress and Antioxidant Defense (2012, background): “For example, methionine can be oxidized methionine sulfoxide 126 and phenylalanine to o -tyrosine 127 ; sulfhydryl groups can be oxidized to form disul fi de bonds; 128 and carbonyl groups may be introduced into the side chains of proteins.”
• Autophagy and Aging: The Importance of Maintaining "Clean" Cells (2005, background): “68 In addition to the direct effect of hydrogen peroxide on the basal IRK activity, hydrogen peroxide further enhances the insulin receptor signaling cascade through inhibition of several phosphatases which normally downregulate its signaling activity by dephosphorylating IRK and PI(3,4,5)P3.”
• Chemical Basis of Reactive Oxygen Species Reactivity and Involvement in Neurodegenerative Diseases (2019, background): “The last pathway for HO• reaction is H-abstraction, for which numerous and various biomolecules are targets as, for instance, polyunsaturated fatty acids such as linoleate [65,66] or arachidonate [67,68], sulfur-containing, basic and aromatic amino acid residues from protein and peptides [69,70], or”
• Activation of chaperone-mediated autophagy during oxidative stress. (2004, background): “Accumulation of oxidized protein is a common feature of aged cells (Dunlop et al., 2002; Grune and Davies, 1997; Grune et al., 2001, 2002b; Stadtman, 2001).”
• Trends in oxidative aging theories. (2007, background): “Such a scenario would explain the age-related accumulation of protein carbonyls (which can be formed by Michael addition of advanced glycation end products; see ([60,61] for a review of the chemistry involved) and the beneficial effect of MrsB overexpression, even though anaerobic conditions do not ”
• Protein Oxidation: Basic Principles and Implications for Meat Quality (2013, background): “In the absence of oxygen, two radicals can combine together to generate cross-linkage within and between proteins (Stadtman, 2001).”