Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications
By Zewen Liu, Tingyang Zhou, Alexander C Ziegler, P. Dimitrion, L. Zuo. Oxidative Medicine and Cellular Longevity, 2017
739 citations recorded by the source corpus.
Increasing numbers of individuals, particularly the elderly, suffer from neurodegenerative disorders. These diseases are normally characterized by progressive loss of neuron cells and compromised motor or cognitive function. Previous studies have proposed that the overproduction of reactive oxygen species (ROS) may have complex roles in promoting the disease development. Research has shown that neuron cells are particularly vulnerable to oxidative damage due to their high polyunsaturated fatty acid content in membranes, high oxygen consumption, and weak antioxidant defense. However, the exact molecular pathogenesis of neurodegeneration related to the disturbance of redox balance remains unclear. Novel antioxidants have shown great potential in mediating disease phenotypes and could be an area of interest for further research. In this review, we provide an updated discussion on the roles of ROS in the pathological mechanisms of Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, and spinocerebellar ataxia, as well as a highlight on the antioxidant-based therapies for alleviating disease severity.
Subfields: Biochemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/9049fd64651effcb8edcc49365ccc16512fc914b
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Biochemistry
In Molecular Biology
Citations in the corpus
- Oxidative Stress: A Key Modulator in Neurodegenerative Diseases (2019, background): “Although pre-clinical studies have shown promising results, the benefit of antioxidant therapy for neurodegenerative diseases is still controversial in humans [143].”
- An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases (2022, background): “the adverse effects of free radicals can be diminished by antioxidants and fruits, such as vitamin C and E [1].”
- Chemical Basis of Reactive Oxygen Species Reactivity and Involvement in Neurodegenerative Diseases (2019, background): “Antioxidant therapy-based strategies to fight against neurodegenerative diseases have shown promising results in preclinical trials but only a few clinical trials have been conducted and the benefit of such a therapy is still under debate [164].”