Genetic control by a metabolite binding mRNA.

By Ali Nahvi, Narasimhan Sudarsan, Margaret S. Ebert, X. Zou, K. Brown, Ronald R. Breaker. Chemistry and Biology, 2002

762 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c064e97ea9b201dc77ce5c6cb6fb03d7010581d8

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Citations in the corpus

Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression (2002, background): “coli can bind coenzyme B 12 selectively, and that this binding event brings about a structural change in the RNA that is important for genetic contro”
Riboswitches and the RNA world. (2012, background): “The characteristics of some riboswitches suggest they could be modern descendents of an ancient sensoryand regulatory system that likely functioned before the emergence of enzymes and genetic factors made of protein (Nahvi et al. 2002; Vitreschak et al. 2004; Breaker 2006).”
Control of gene expression by a natural metabolite-responsive ribozyme (2004, background): “However, it has been determined recently that specialized domains within certain mRNAs selectively bind metabolites and control gene expression without the need for protein factor”
Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. (2014, background): “Although Apts can exist naturally in riboswitches [277-279], most of the Apts used for the design and synthesis of targeted NPs are artificially-engineered.”
RNA-Puzzles Round II: assessment of RNA structure prediction programs applied to three large RNA structures (2015, background): “For Problem 6, several secondary structure models had been proposed in the literature (Ravnum and Andersson 2001; Nahvi et al. 2002, 2004; Vitreschak et al. 2003; Barrick and Breaker 2007), and the M 2 analysis was important for unambiguously confirming the correct model.”
RNA origami scaffolds facilitate cryo-EM characterization of a Broccoli–Pepper aptamer FRET pair (2023, background): “RNA molecules have the ability to fold into complex structures with binding and catalytic properties such as smallmolecule binding RNAs (1), riboswitches (2,3) and ribozymes (4,5).”
A decade of riboswitches. (2013, positive): “Following their first description 10 years ago (Mironov et al., 2002; Nahvi et al., 2002; Winkler et al., 2002), riboswitches have become recognized as important and widespread elements in the control of gene expression in numerous evolutionarily distant bacteria, with counterparts in archaea, plant”
RNA target highlights in CASP15: Evaluation of predicted models by structure providers (2023, background): “27 Riboswitches regulate downstream genes by use of an aptamer domain that senses a cellular metabolite with high specificity.”
Recent advances in RNA structurome (2022, background): “Since the first discovery of riboswitches in 2002 (Mironov et al., 2002; Nahvi et al., 2002; Winkler et al., 2002a; Winkler et al., 2002b), more than 45 riboswitches have been identified to date (McCown et al., 2017).”
Gene regulation by riboswitches (2004, background): “Numerous mRNAs in prokaryotes carry complex folded domains, which are known as riboswitche”
Regulation of bacterial gene expression by riboswitches. (2005, background): “To date, reports of nine separate riboswitch classes have been made in which there is direct evidence of metabolite binding in the absence of protein factors (Figure 3 )( Table 2). Varying levels of biochemical and genetic evidence for riboswitch classes that sense coenzyme B12 (59, 60 ), TPP (55, ”
TonB-dependent transporters: regulation, structure, and function (2010, background): “Further experiments demonstrated that AdoCbl binding to the btuB leader induced a structural change (62).”
Coarse-grained modeling of large RNA molecules with knowledge-based potentials and structural filters. (2009, background): “1983), and riboswitches, which are sequences within some mRNAs that change conformations upon binding small metabolites and subsequently terminate transcription or block translation (Nahvi et al. 2002; Winkler et al. 2002a,b; Rodionov et al. 2003; Vitreschak et al. 2004).”