Regulation of bacterial gene expression by riboswitches.

By W. Winkler, Ronald R. Breaker. Annual Review of Microbiology, 2005

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Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline (2007, background): “Cis-regulatory RNAs often have one of two noteworthy structural features: rho-independent transcription terminators, or stems that overlap the Shine–Dalgarno sequence (bacterial ribosome-binding site) (16).”
Implications of streamlining theory for microbial ecology (2014, background): “Although not unique to organisms with streamlined genomes (Winkler and Breaker, 2005), noncoding RNAs represent a simple solution to regulation in the context of fewer genes and many have been cataloged in Pelagibacter (Meyer et al., 2009; Tripp et al., 2009; Smith et al., 2010) and Prochlorococcus…”
RNA synthetic biology (2006, background): “Engineered ligand-controlled riboregulators Recent studies have shown that many essential genes in bacteria rely on RNA-based mechanisms such as riboswitches for post-transcriptional control of gene expressio”