Control of gene expression by a natural metabolite-responsive ribozyme

By W. Winkler, Ali Nahvi, Adam Roth, J. Collins, Ronald R. Breaker. Nature, 2004

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Riboswitches and the RNA world. (2012, background): “Riboswitch aptamers can tightly bind their target ligands with values for dissociation constants (KD) ranging from the mid micromolar as measured for GlcN6P binding by glmS ribozymes (Winkler et al. 2004) to the mid picomolar range as observed for some riboswitch representatives that bind TPP (Welz ”
Gene regulation by riboswitches (2004, background): “This compound selectively triggers a novel SELF-CLEAVING RIBOZYME that is located in the 5′-UTR of the mRN”
A decade of riboswitches. (2013, positive): “This noncoding RNA is typically found in Gram-positive bacteria, where it interacts with glucosamine-6-phosphate (GlcN6P), which, after binding, cleaves the glmS mRNA within the riboswitch sequence (Figure 1B) (Winkler et al., 2004).”
RNA synthetic biology (2006, background): “Engineered ribozyme-mediated RNA switches Research on riboswitches has shown that direct interaction of intracellular metabolites and RNA sequences can affect translation and transcription through RNA self-cleavag”
Regulation of bacterial gene expression by riboswitches. (2005, background): “Many different posttranscriptional control mechanisms have been identified during the past few decades, including those that regulate transcription elongation, transcription termination, translation initiation, translation termination, and mRNA stability (3, 11, 12, 20, 56, 85, 86, 107 ).”