Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression

By W. Winkler, Ali Nahvi, Ronald R. Breaker. Nature, 2002

1,217 citations recorded by the source corpus.

Subfields: Genetics, Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6d396839346f0c21000869b10d9c391332e91a89

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Citations in the corpus

Regulation of bacterial gene expression by riboswitches. (2005, background): “To date, reports of nine separate riboswitch classes have been made in which there is direct evidence of metabolite binding in the absence of protein factors (Figure 3 )( Table 2). Varying levels of biochemical and genetic evidence for riboswitch classes that sense coenzyme B12 (59, 60), TPP (55, 1”
Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. (2014, background): “Although Apts can exist naturally in riboswitches [277-279], most of the Apts used for the design and synthesis of targeted NPs are artificially-engineered.”
Design, construction and characterization of a set of insulated bacterial promoters (2010, background): “For example, natural and synthetic riboregulators located in the 50-untranslated region allow for small-molecule control of translation (43,44).”
Control of gene expression by a natural metabolite-responsive ribozyme (2004, background): “However, it has been determined recently that specialized domains within certain mRNAs selectively bind metabolites and control gene expression without the need for protein factor”
Toehold Switches: De-Novo-Designed Regulators of Gene Expression (2014, neutral): “Nature has already developed a wide assortment of RNA-based parts operating at the transcriptional and posttranscriptional level (Brantl and Wagner, 2000; Gultyaev et al., 1997;Winkler et al., 2002).”
Recent advances in RNA structurome (2022, background): “…alternative RNA tertiary fold containing multiple long-range interactions followed by a stable sequester stem unfavorable to translation initiation, thus negatively regulating the expression of genes associated with FMN biosynthesis (Howe et al., 2015; Serganov et al., 2009; Winkler et al., 2002b).”
Coarse-grained modeling of large RNA molecules with knowledge-based potentials and structural filters. (2009, background): “These diverse molecules include RNA enzymes (ribozymes), which catalyze RNA cleavage (Stark et al. 1978; Kruger et al. 1982; Guerrier-Takada et al. 1983), and riboswitches, which are sequences within some mRNAs that change conformations upon binding small metabolites and subsequently terminate trans”
Gene regulation by riboswitches (2004, background): “Numerous mRNAs in prokaryotes carry complex folded domains, which are known as riboswitche”
A decade of riboswitches. (2013, neutral): “Eventually, three vitamin derivatives, thiamine pyrophosphate (TPP) (Mironov et al., 2002; Winkler et al., 2002), flavin”
Riboswitches and the RNA world. (2012, background): “The most widespread riboswitch class discovered to date responds to the coenzyme thiamin pyrophosphate (TPP) (Mironov et al. 2002; Winkler et al. 2002b; Barrick and Breaker 2007).”