The inflammatory reflex

By Kevin J. Tracey. Nature, 2002

3,633 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/bf4ad69feceb4719519b726c2337e8fb6b7abe43

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In Endocrine and Autonomic Systems

In Molecular Biology

In Neurology

Citations in the corpus

Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens (2006, background): “This is the first step in the 'inflammatory reflex', which leads to the release of acetylcholine from efferent vagus nerve fibres and resultant negative-feedback control of inflammatio”
The Cholinergic Anti-inflammatory Pathway: A Missing Link in Neuroimmunomodulation (2003, background): “This previously unrecognized immunomodulatory circuit termed the “cholinergic anti-inflammatory pathway” is a mechanism for neural inhibition of inflammation (18,19), and interfaces the brain with the immune system.”
The role of inflammation in epilepsy (2010, neutral): “50”
Cytokines and major depression. (2005, background): “studied by Yirmiya (1996). The effects of the bacterial endotoxin LPS, which is a potent activator of the immune system, on affective and cognitive functions were investigated in healthy human volunteers.”
Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia (2008, background): “However, this observation does not take into account the requirement of nicotinic acetylcholine receptor 7 subunit signaling in the cholinergic antiinflammatory pathway (3, 28).”
Adverse childhood experiences, allostasis, allostatic load, and age-related disease. (2012, background): “The elevation in inflammation levels is presumably due to the chronic or repeated stimulation of the sympathetic nervous system [15], as well as to the progressive down-regulation of key anti-inflammatory pathways, such as the HPA axis [24,28] and the parasympathetic nervous system [29,30].”
Systemic infections and inflammation affect chronic neurodegeneration (2007, background): “First, inflammatory events in the thoracic abdominal cavity are signalled to the brain through vagal-nerve sensory afferents, and in turn the vagal efferent outflow might modify these inflammatory events through acetylcholine secretio”
Immune modulation of learning, memory, neural plasticity and neurogenesis. (2011, neutral): “Since both in the periphery and the brain ACh produces anti-inflammatory effects (Pollak et al., 2005; Tracey, 2002), elevation of AChE activity can produce further cytokine secretion and such effects were suggested to be involved in stress- and endotoxin-induced memory disturbances in humans…”
The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation (2007, background): “Nicotine exerts anti-inflammatory effects on macrophages that can be counteracted by selective a7-antagonists (Tracey, 2002; Wang et al., 2003; Ulloa, 2005).”
Anxiety Disorders are Associated with Reduced Heart Rate Variability: A Meta-Analysis (2014, background): “This chronicity may in turn contribute to chronic withdrawal of the parasympathetic nervous system, and subsequent impairment in the cholinergic anti-inflammatory reflex (107), leading to an increase in a host of conditions including diabetes, obesity, and CVD (9, 10).”
Physiology and immunology of the cholinergic antiinflammatory pathway. (2007, positive): “Accord-ingly, it seemed possible to posit the existence of a comparable mechanism to control cytokine release that could, at least in theory, function as an extremely fast, reflex-like antiinflammatory pathway controlled by brain networks (14).”
Sepsis: current dogma and new perspectives. (2014, background): “The inflammatory reflex is a prototypical, major efferent neural pathway that modulates TNF release in response to LPS (Figure 2) (Tracey, 2002, 2009; Borovikova et al., 2000).”