The Cholinergic Anti-inflammatory Pathway: A Missing Link in Neuroimmunomodulation
By Valentin A. Pavlov, Hong Wang, C. Czura, S. Friedman, Kevin J. Tracey. Molecular Medicine, 2003
709 citations recorded by the source corpus.
This review outlines the mechanisms underlying the interaction between the nervous and immune systems of the host in response to an immune challenge. The main focus is the cholinergic anti-inflammatory pathway, which we recently described as a novel function of the efferent vagus nerve. This pathway plays a critical role in controlling the inflammatory response through interaction with peripheral α7 subunit-containing nicotinic acetylcholine receptors expressed on macrophages. We describe the modulation of systemic and local inflammation by the cholinergic anti-inflammatory pathway and its function as an interface between the brain and the immune system. The clinical implications of this novel mechanism also are discussed.
Subfields: Endocrine and Autonomic Systems, Molecular Biology, Neurology
View Paper: https://www.semanticscholar.org/paper/a6e36b171a33f194b51e268f7d8d613af09c8545
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In Endocrine and Autonomic Systems
In Molecular Biology
In Neurology
Citations in the corpus
- Brain-gut interactions in inflammatory bowel disease. (2013, background): “Acetylcholine (ACh), released at the distal end of VN efferents, decreases the production of proinflammatory cytokines such as TNF by human macrophages through alpha7 nicotinic ACh receptor (a7nAChR) expressed by macrophages (26) (Figure 3).”
- The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis (2018, background): “In particular, VN stimulation (VNS), approved for the treatment of depression and epilepsy (Ben-Menachem, 2001; Bonaz et al., 2013) and for its antiinflammatory properties (Borovikova et al., 2000a,b; Pavlov et al., 2003), should be of interest.”