Adverse childhood experiences, allostasis, allostatic load, and age-related disease.

By A. Danese, Bruce S. McEwen. Physiology and Behavior, 2012

1,940 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Developmental Neuroscience, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/8febd8193461fb35a5fd43fcf0596a18dc991c27

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In Behavioral Neuroscience

In Developmental Neuroscience

In Pediatrics, Perinatology and Child Health

Citations in the corpus

Paradise Lost: The Neurobiological and Clinical Consequences of Child Abuse and Neglect. (2016, background): “The results were striking and conclusive; 64% of the respondents had, at least, one ACE.”
Brain On Stress: Vulnerability and Plasticity of the Prefrontal Cortex Over the Life Course (2013, neutral): “…levels compared to nonmaltreated children, while adults with a history of childhood maltreatment showed smaller volume of the prefrontal cortex and hippocampus, greater activation of the HPA axis, and elevation in inflammation levels compared to nonmaltreated individuals (Danese and McEwen, 2012).”
The Relationship between Adverse Childhood Experiences (ACE) and Juvenile Offending Trajectories in a Juvenile Offender Sample (2015, background): “…more recently a dose-response relationship has been identified between ACEs with negative neurological consequences, such as chromosome damage (Shalev et al., 2013) and functional changes to the developing brain (Anda et al., 2010; Cicchetti, 2013; Danese & McEwen, 2012; Teicher et al., 2003).”
The Effects of Stress on Physical Activity and Exercise (2014, neutral): “Typically, this has been utilized to explain how chronic stressors relate to physiological maladaptations in middle and later life [32]; however, mounting evidence also implicates traumatic childhood experiences, stressors that have a reverberating impact for decades [33, 34].”
Adverse Childhood Experiences, Negative Emotionality, and Pathways to Juvenile Recidivism (2017, background): “…as well as teenage pregnancy, sexually risky behaviors (Hillis et al., 2004; Hillis, Anda, Felitti, & Marchbanks, 2001), and even chromosome damage (Shalev et al., 2013) and functional changes to the developing brain (Anda et al., 2010; Cicchetti, 2013; Danese & McEwen, 2012; Teicher et al., 2003).”
Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters. (2018, neutral): “…countries do not only reflect chronic inflammation, but also non-inflammatory upregulation of repair mechanisms in response to other sources of tissue damage—for example environmental pollutants, drugs such as alcohol and tobacco, and other toxic chemicals (e.g., Danese & McEwen, 2012).”
Predicting Adverse Childhood Experiences (2017, background): “…has been linked to myriad of negative outcomes, including immediate chromosomal and functional brain damage (Anda et al., 2010; Cicchetti, 2013; Danese & McEwen, 2012; Shalev et al., 2013; Teicher et al., 2003), proximal behavioral issues (Bellis et al., 2014), and more distal negative health…”
The Interrelatedness of Adverse Childhood Experiences Among High-Risk Juvenile Offenders (2016, background): “ACE scores have more recently been identified with immediate negative consequences such as chromosome damage (Shalev et al., 2013) and functional changes to the developing brain (Anda et al., 2010; Cicchetti, 2013; Danese & McEwen, 2012; Teicher et al., 2003).”
Adult health outcomes of childhood bullying victimization: evidence from a five-decade longitudinal British birth cohort. (2014, background): “Finally, in line with hypotheses derived from theories of the biological embedding of stress (40), previous studies have shown that bullying victimization in childhood is associated with a blunted cortisol response (41) and higher serotonin transporter gene methylation levels (42).”