Immune modulation of learning, memory, neural plasticity and neurogenesis.

By R. Yirmiya, I. Goshen. Brain, behavior, and immunity, 2011

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How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Inflammatory Cytokines in Depression: Neurobiological Mechanisms and Therapeutic Implications (2013, background): “Cytokines are important in brain development, and can promote healthy brain function by supporting neuronal integrity, neurogenesis, and synaptic remodeling (Yirmiya and Goshen, 2011).”
Visceral influences on brain and behavior. (2013, neutral): “Cytokines are even implicated in healthy hippocampus-dependent memory function (Yirmiya and Goshen, 2011).”
Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017, background): “Inflammatory challenges increase IL-1 in the medial temporal lobe (Ban et al, 1992) and also facilitate deficits in memory performance and contextual fear conditioning in rodents (Pugh et al, 1998; Yirmiya and Goshen, 2011).”
Cytokine Targets in the Brain: Impact on Neurotransmitters and Neurocircuits (2013, methodology): “[51–53] In addition, recent data suggest that activation of cytokines including TNF and IFN-γ may play an important role in the molecular and behavioral response to antidepressants.”
The Bidirectional Relationship of Depression and Inflammation: Double Trouble (2020, background): “In the brain, cytokines produced by microglia and other CNS cells are crucial positive modulators of several CNS functions, such as maintenance of neuroplasticity (Stellwagen and Malenka, 2006; Yirmiya and Goshen, 2011).”