Physiology and immunology of the cholinergic antiinflammatory pathway.

By Kevin J. Tracey. Journal of Clinical Investigation, 2007

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A healthy heart is not a metronome: an integrative review of the heart's anatomy and heart rate variability (2014, background): “In younger healthy individuals, it is not uncommon to see an obvious increase in the HF band at night with a decrease during the day (Lombardi et al., 1996; Otsuka et al., 1997).”
The Gut Microbiota and Alzheimer’s Disease (2017, positive): “…effect of vagus nerve stimulation is still unkown, it may activate the anti-inﬂammatory pathway releasing ACh which binds to (cid:5) -7-nicotinic ACh receptors ( (cid:5) 7 nAChRs) of macrophages to inhibit the release of proinﬂammatory cytokines (i.e., TNF (cid:5) ) (for review, see [163, 164]).”
Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia (2008, background): “Discussion The results herein expand our knowledge of the anatomical basis of the cholinergic antiinflammatory pathway (28, 29).”
Harmful molecular mechanisms in sepsis (2008, background): “The efferent arm of the inflammatory reflex is the cholinergic anti-inflammatory pathwa”
Sepsis: current dogma and new perspectives. (2014, background): “…been suggested that pharmacological agents, including statins and centrally cholinergic agonists, might confer a survival advantage by enhancing vagus nerve and thereby restoring the anti-inflammatory activity of the inflammatory reflex (Werdan et al., 2009; Satapathy et al., 2011; Tracey, 2007).”