Loss of IGF2 Imprinting: A Potential Marker of Colorectal Cancer Risk

By H. Cui, M. Cruz-Correa, F. Giardiello, D. Hutcheon, D. Kafonek, S. Brandenburg, Yiqian Wu, Xiaobing He, N. Powe, Andrew P. Feinberg. Science, 2003

782 citations recorded by the source corpus.

Subfields: Genetics, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/bf1dac5ba3d755aa27bcde692b39069413ea73ac

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Citations in the corpus

Cancer epigenetics. (2005, background): “One such systemic epigenetic control defect appears to be loss of imprinting of the IGF2 locus, which occurs in the colorectal tumors, and in the normal colonic mucosa and white blood cells of individuals with colorectal cancer, or with a family history of colorectal cancer (159,160).”
Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction? (2006, background): “gov/cancertopics/types/wilms">Wilms tumour , and also to the early stages of colorectal and other cancer”
The epigenetic progenitor origin of human cancer (2006, background): “Hypomethylation generally arises earlier and is strongly linked to chromosomal instability and loss of imprintin”
Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker. (2004, background): “(9) in a recent issue of Science and by Rhodes et al.”
DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. (2009, background): “Previous work on IGF2 DMR has shown that methylation in blood can mark the methylation level in a relevant tissue (37).”
Insulin-like growth factors and neoplasia (2004, background): “and that loss of imprinting of IGF2 represents a risk factor for colorectal cance”
The history of cancer epigenetics (2004, background): “7 for patients with a past history, of colorectal cance”
Phenotypic plasticity and the epigenetics of human disease (2007, background): “, and is associated with a fivefold increased frequency of benign and malignant colorectal neoplasms (and 20-fold for cancer), as well as an increased family history of cancer, consistent with a causal role in cancer predispositio”
Mendelian Inheritance in Man and Its Online Version, OMIM (2007, neutral): “74 found that the adjusted odds ratio for LOI of IGF2 in lymphocytes was 5.15 for patients with a positive family history, 3.46 for patients with adenomas, and 21.7 for patients with colorectal cancer.”
DNA hypomethylation and human diseases. (2007, background): “Further, LOI of IGF2 has been implicated as a precursor lesion in colorectal cancer, with individuals showing systemic LOI having a higher risk of developing colorectal cancer [97].”
Epigenetics in human disease and prospects for epigenetic therapy (2004, background): “For example, the finding that loss of imprinting can be seen not only in normal colonic epithelium but also in the lymphocytes of colorectal patients was completely unexpecte”
High-throughput DNA methylation profiling using universal bead arrays. (2006, background): “In contrast, a global hypomethylation of genomic DNA (Feinberg and Vogelstein 1983) and loss of IGF2 imprinting were observed in tumor cells (Cui et al. 2003; Sakatani et al. 2005); and a correlation between hypomethylation and increased gene expression was reported for many oncogenes (Feinberg and…”
Is folic acid good for everyone? (2008, background): “Loss of imprinting, which leads to biallelic expression of IGF2 in lymphocytes, has been found in 10% of the normal population and was associated with hypomethylation of the differentially methylated region of IGF2 (158).”