Phenotypic plasticity and the epigenetics of human disease

By Andrew P. Feinberg. Nature, 2007

1,615 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5c841152215b0d1526596fcd872687302b82c438

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Citations in the corpus

How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers (2007, background): “It has become increasingly clear that epigenetic changes, such as DNA and histone methylation, contribute to the progression of human disease (see ref”
MLL translocations, histone modifications and leukaemia stem-cell development (2007, background): “The information presented here combined with recent studies that assess this epigenetic state in human cancer”
Intratumor heterogeneity: the Rosetta stone of therapy resistance (2020, background): “…this increased cell-to-cell variability might also be a consequence of global epigenetic changes, generally observed in cancer cell epigenomes (such as global hypomethylation of CpG islands) (Feinberg, 2007), and can be summarized as higher entropy of the cancer epigenome (Jenkinson et al., 2017).”
Long non-coding RNAs: a new frontier in the study of human diseases. (2013, background): “It has been revealed that DNA methylation plays a key regulatory role in normal development, and aberrations in epigenetic modifications can cause diseases such as cancers [59].”
Nutrition and epigenetics: An interplay of dietary methyl donors, one-carbon metabolism, and DNA methylation (2012, neutral): “Additionally, cancer is often associated with hypomethylated DNA and notable hypermethylation of tumor suppressor genes, as compared to normal tissue [17].”
Ten Putative Contributors to the Obesity Epidemic (2009, positive): “Several molecular mechanisms including methylation of cytosines within CpG dinucleotides, various modifications of the histone proteins that package DNA in the nucleus, and cell-autonomous expression of myriad autoregulatory DNA binding proteins interact to perpetuate the regional chromatin conforma”
Homeostasis, Inflammation, and Disease Susceptibility (2015, positive): “However, if the environment is not as anticipated and the phenotypic choice is irreversible, maladapted phenotypes susceptible to disease may result (Dewitt et al., 1998; Feinberg, 2007; Stearns and Koella, 2008).”
Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities (2018, background): “1 Curing monogenic disorders—Monogenic disorders are diseases arising from a single gene defect in the genome [106, 107].”
Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays (2014, positive): “The health implications of deciphering the DNAm code have recently received much attention (Dawson and Kouzarides, 2012; Feinberg, 2007).”
Epigenetics and the biological definition of gene x environment interactions. (2010, background): “This perspective was further reinforced by findings showing that an alteration of DNA methylation at critical genomic targets (i.e., tumor suppressors) is associated with cancer (Eden, Gaudet, Waghmare, & Jaenisch, 2003; Feinberg, 2007; Laird, 2005).”