The epigenetic progenitor origin of human cancer

By Andrew P. Feinberg, R. Ohlsson, Steven Henikoff. Nature reviews genetics, 2006

1,935 citations recorded by the source corpus.

Subfields: Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/0feb0833012e0e542e050c156fa0c8a408db08f0

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In Pediatrics, Perinatology and Child Health

Citations in the corpus

Genetic determinants of cancer metastasis (2007, background): “On the other hand, it has been postulated that epigenetic modulators of cell plasticity can initiate the malignant phenotype by conferring a stem or progenitor stat”
Polycomb group proteins: navigators of lineage pathways led astray in cancer (2009, neutral): “It is becoming increasingly evident that, in addition to genetic alterations, tumour development involves the alteration of gene expression patterns owing to epigenetic change”
DNA hypomethylation and human diseases. (2007, background): “Feinberg and colleagues state [32], “Although individual genes vary in hypomethylation, all tumors examined so far, both benign and malignant have shown global reduction of DNA methylation.”
Cancer metastasis: building a framework. (2006, background): “Moreover, epigenetic plasticity must be recognized as an important source of cancer-cell heterogeneity (Baylin and Ohm, 2006; Feinberg et al., 2006).”
Active DNA Demethylation Mediated by DNA Glycosylases (2009, neutral): “In many cancers, bulk genome DNA methylation levels are reduced (22, 25, 104).”
DNA methylation and cancer. (2010, background): “It has been proposed that epigenetic disruptions are the initiating events leading to the occurrence of “cancer progenitor cells” (Feinberg et al., 2006).”
Genome-wide methylation analysis of human colon cancer reveals similar hypo- and hypermethylation at conserved tissue-specific CpG island shores (2009, result): “These data are consistent with the epigenetic progenitor model of cance”
A decade of exploring the cancer epigenome — biological and translational implications (2011, background): “This scenario may well illustrate that epigenetic changes can be the earliest initiating factor in a human cance”
Phenotypic plasticity and the epigenetics of human disease (2007, background): “Cancer epigenetics and the stem-cell hypothesis Although epigenetic alterations are commonly looked on as surrogates for genetic change in cancer, they are probably also critical first steps in neoplastic progression, disrupting the normal stem- or progenitor-cell programme, for example by stimul”
The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak (2008, background): “Epigenetic processes, such as DNA or histone methylation and histone acetylation, produce heritable but potentially reversible changes in DNA or its associated proteins, and are prominent in developmental processes and oncogenesis ( 1 ).”
DNA methylation: superior or subordinate in the epigenetic hierarchy? (2011, background): “Early aberrant epigenetic changes may occur in normal cells under stress conditions such as chronic inflammation, well before tumors arise.(22,80) Feinberg et al.”
The mammalian epigenome. (2007, background): “This model suggests that cancer may evolve from a population of nonneoplastic, polyclonal, epigenetically disrupted stem/progenitor cells, potentially with additional genetic lesions (Feinberg et al., 2006; see also the Review by P.A. Jones and S.B. Baylin, page 683 of this issue).”